Kryzhanovskiĭ G N, Atadzhanov M A, Voronina T A, Nerobkova L N
Biull Eksp Biol Med. 1989 May;107(5):522-5.
Rats with the Parkinsonian syndrome induced by administration of acetyl choline and proserine into the rostral part of both caudate nuclei manifest an increased electrical activity (EA) in this part. Tremor, oligokinesia and rigidity are characterized by the appearance of paroxysmal EA with high amplitude of slow and rapid waves. The data obtained allow to conclude that neuropathophysiological basis of the Parkinsonian syndrome is the formation of the generator of pathologically enhanced excitation (GPEE) in the caudate nuclei. Some peculiarities of the GPEE activity in tremor and akinetic rigidity syndromes were observed. Intrarostral administration of dopamine or intraperitoneal administration of cyclodol resulted in the inhibition of GPEE and disappearance of clinical manifestations of Parkinsonian syndrome.
通过向双侧尾状核头部注射乙酰胆碱和毒扁豆碱诱导出帕金森综合征的大鼠，其该部位的电活动（EA）增强。震颤、运动减少和强直的特征是出现高振幅慢波和快波的阵发性EA。所得数据表明，帕金森综合征的神经病理生理基础是尾状核中病理性增强兴奋发生器（GPEE）的形成。观察到GPEE活动在震颤和运动不能性强直综合征中的一些特点。向尾状核头部内注射多巴胺或腹腔注射安坦可导致GPEE受到抑制，帕金森综合征的临床表现消失。
