Rogatskiĭ G G, Golikov P P, Nikolaeva N Iu, Vaĭnshteĭn M B
Biull Eksp Biol Med. 1989 May;107(5):545-7.
The three series of experiments conducted on 139 adult wistar rats it was found, that two-hour stay of the animals in barochamber under the pressure of 3 atmospheres reduces considerably the percentage of mortality rate and decelerates the development of arterial hypoxemia in rats with an experimental model of acute respiratory distress syndrome (ARDS) reproduced by intrapleural injection of oleic acid (0.27 ml/100 g). Stalle in comparison with the control (I) series elevation of corticosterone in the animal blood II and III series (conduction of HBO correspondingly in 4 and 12 hours from the beginning of the process) is considered as the manifestation of one of the most important mechanism of organism adaptation to the development of acute hypoxia in ARDS.
在对139只成年Wistar大鼠进行的三组实验中发现，在3个大气压的压力下，将动物置于高压舱中两小时，可显著降低急性呼吸窘迫综合征（ARDS）实验模型（通过胸腔内注射油酸（0.27 ml/100 g）复制）大鼠的死亡率，并减缓动脉低氧血症的发展。与对照组（I组）相比，II组和III组动物血液中皮质酮升高（分别在过程开始后的4小时和12小时进行高压氧治疗），被认为是机体适应ARDS急性缺氧发展的最重要机制之一的表现。
