[Effect of amino acid derivatives of beta-carboline-3-carboxylate on rat behavior].
作者信息
Pliashkevich Iu G, Barsegian G G, Ponomarev S Iu, Demushkin V P
出版信息
Biull Eksp Biol Med. 1989 May;107(5):586-7.
PMID:2736294
Abstract
It was shown, that administration of methyl ether N-(beta-carboline-3-carbonyl)-glycine (GA) at dose level of 1-10 mg/kg markedly reduced exploratory behavior and motor activity in the open field test and facilitated manifestation of different rats defend reaction types. Methyl ether N-(beta-carboline-3-carbonyl)-leucine (LA) at the same doses was less effective. Besides GA (10 mg/kg) like earlier described anxiogenic compound FG 7142 suppressed isolation induced muricide behavior of rats. The results obtained combined with literary data allow us to conclude, that GA possesses expressed anxiogenic activity.
摘要
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