Garni Martina, Einfalt TomaŽ, Lomora Mihai, Car Anja, Meier Wolfgang, Palivan Cornelia G
University of Basel, Department of Chemistry, Klingelbergstrasse 80, CH-4056 Basel, Switzerland.
Chimia (Aarau). 2016;70(6):424-7. doi: 10.2533/chimia.2016.424.
Reactions inside confined compartments at the nanoscale represent an essential step in the development of complex multifunctional systems to serve as molecular factories. In this respect, the biomimetic approach of combining biomolecules (proteins, enzymes, mimics) with synthetic membranes is an elegant way to create functional nanoreactors, or even simple artificial organelles, that function inside cells after uptake. Functionality is provided by the specificity of the biomolecule(s), whilst the synthetic compartment provides mechanical stability and robustness. The availability of a large variety of biomolecules and synthetic membranes allows the properties and functionality of these reaction spaces to be tailored and adjusted for building complex self-organized systems as the basis for molecular factories.
纳米尺度受限隔室内的反应是开发用作分子工厂的复杂多功能系统的关键一步。在这方面，将生物分子（蛋白质、酶、模拟物）与合成膜相结合的仿生方法是创建功能性纳米反应器甚至简单人工细胞器的巧妙方式，这些纳米反应器和人工细胞器在被摄取后能在细胞内发挥作用。生物分子的特异性赋予了功能，而合成隔室则提供了机械稳定性和坚固性。大量生物分子和合成膜的可得性使得这些反应空间的性质和功能能够被定制和调整，以构建复杂的自组织系统作为分子工厂的基础。
