Nicoletti A, Luca A, Luca M, Donzuso G, Mostile G, Raciti L, Contrafatto D, Dibilio V, Sciacca G, Cicero C E, Vasta R, Petralia A, Zappia M
Section of Neurosciences, Department GF Ingrassia, University of Catania, Catania, Italy.
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Parkinsonism Relat Disord. 2016 Sep;30:36-9. doi: 10.1016/j.parkreldis.2016.06.015. Epub 2016 Jun 21.
aim of the study was to evaluate the presence of the Obsessive Compulsive Personality Disorder (OCPeD) in Multiple System Atrophy (MSA), Progressive Supranuclear Palsy (PSP) and Essential Tremor (ET) and in a group of healthy subjects.
patients affected by MSA, PSP and ET diagnosed according to currently accepted diagnostic criteria and a group of healthy controls were enrolled in the study. Patients with cognitive impairment were excluded from the study. The Structured Clinical Interview for Personality Disorders-II (SCID-II) has been performed to evaluate the presence of personality disorders (PeDs). The diagnosis of OCPeD was confirmed by a psychiatric interview.
fifteen MSA patients (8 men and 7 women; aged 62.9 ± 7.6 years), 14 PSP patients (8 men and 6 women; aged 69.8 ± 4.4 years), 16 ET patients (10 men and 6 women; aged 70.4 ± 6.4 years) and 20 healthy subjects (10 men and 10 women; aged 65.5 ± 6.0 years) were enrolled. OCPeD was recorded in 5 (35.7%) PSP patients, 2 (13.3%) MSA patients, 2 (12.5%) ET patient and 2 (10%) controls.
a low frequency of OCPeD, close to those recorded in healthy subjects, was recorded in both MSA and ET patients. Conversely an higher frequency of OCPeD, similar to PD was found among PSP patients, supporting the possibility of an impairment of common basal ganglia network possibly involving the orbito-frontal circuits.
本研究的目的是评估多系统萎缩（MSA）、进行性核上性麻痹（PSP）、特发性震颤（ET）以及一组健康受试者中强迫型人格障碍（OCPeD）的存在情况。
根据目前公认的诊断标准确诊的MSA、PSP和ET患者以及一组健康对照者纳入本研究。认知功能障碍患者被排除在研究之外。采用人格障碍结构化临床访谈第二版（SCID-II）评估人格障碍（PeDs）的存在情况。OCPeD的诊断通过精神科访谈得以确认。
纳入了15例MSA患者（8例男性，7例女性；年龄62.9±7.6岁）、14例PSP患者（8例男性，6例女性；年龄69.8±4.4岁）、16例ET患者（10例男性，6例女性；年龄70.4±6.4岁）和20例健康受试者（10例男性，10例女性；年龄65.5±6.0岁）。5例（35.7%）PSP患者、2例（13.3%）MSA患者、2例（12.5%）ET患者和2例（10%）对照者被记录存在OCPeD。
MSA和ET患者中OCPeD的发生率较低，与健康受试者中的记录相近。相反，PSP患者中OCPeD的发生率较高，与帕金森病患者相似，这支持了共同的基底神经节网络可能受损且可能涉及眶额回路的可能性。
