Sumida Tomoki, Ishikawa Akiko, Mori Yoshihide
Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Japan.
Cancer Genomics Proteomics. 2016 Jul-Aug;13(4):305-10.
Salivary gland cancer is a common type of head and neck cancer characterized by occasional deep invasion and lung metastasis. The precise role of sex steroid hormones in salivary gland cancer is unclear. To address this issue, we investigated whether the estrogen axis modulates salivary adenocarcinoma (SAC) and whether hormone therapy can be an effective treatment.
The estrogen receptor (ER) was overexpressed in HSG human SAC cells that lack endogenous ER and the cells were treated with and without 17β-estradiol (E2).
E2 enhanced malignant phenotypes. Moreover, E2 treatment reduced E-cadherin expression, while increasing that of N-cadherin, vimentin, and inhibitor of differentiation 1 proteins that are associated with the epithelial-mesenchymal transition. Cell invasion was enhanced through activation of matrix metalloproteinase-9.
These results indicate that hormone therapy used in breast cancer may also be effective for ER-positive SAC.
唾液腺癌是一种常见的头颈部癌症，其特征是偶尔会发生深度浸润和肺转移。性类固醇激素在唾液腺癌中的具体作用尚不清楚。为解决这一问题，我们研究了雌激素轴是否调节唾液腺腺癌（SAC）以及激素疗法是否可以成为一种有效的治疗方法。
雌激素受体（ER）在缺乏内源性ER的HSG人唾液腺癌细胞中过表达，并且对细胞进行有或没有17β-雌二醇（E2）的处理。
E2增强了恶性表型。此外，E2处理降低了E-钙黏蛋白的表达，同时增加了与上皮-间质转化相关的N-钙黏蛋白、波形蛋白和分化抑制因子1蛋白的表达。通过激活基质金属蛋白酶-9增强了细胞侵袭。
这些结果表明，用于乳腺癌的激素疗法可能对ER阳性的SAC也有效。
