Liu P Y
Zhonghua Liu Xing Bing Xue Za Zhi. 1989 Apr;10(2):109-12.
The immunogenic effect of intradermal inoculation of small dose of HB vaccine was evaluated in 120 seronegative villagers (men: 55, women: 65) whose ages were from 3 to 70. These participants were randomly divided into subcutaneous group (I) and intradermal group (II). The results showed that the anti-HBs seroconversion rates and P/N ratios of those who showed the seroconversion for group I, II were 98.4%, 98.3% and 88.0, 89.4, respectively after the third injection. There was no significant difference between the groups in the seroconversion rates and their P/N ratios (P greater than 0.05). It is concluded that in these two groups small doses of HB vaccine have stimulated high immune responses. Intradermal small dose regimen is safe, more economic and will make the HB vaccine available to more people.
对120名年龄在3至70岁之间的血清学阴性村民（男性55名，女性65名）评估了小剂量乙肝疫苗皮内接种的免疫原性效果。这些参与者被随机分为皮下接种组（I组）和皮内接种组（II组）。结果显示，I组和II组在第三次注射后出现血清转化者的抗-HBs血清转化率和P/N比值分别为98.4%、98.3%和88.0、89.4。两组在血清转化率及其P/N比值方面无显著差异（P大于0.05）。结论是，在这两组中，小剂量乙肝疫苗均激发了较高的免疫反应。皮内小剂量接种方案安全、更经济，将使更多人能够接种乙肝疫苗。
