Vashi Neeti, Stryjecki Carolina, Peralta-Romero Jesus, Suarez Fernando, Gomez-Zamudio Jaime, Burguete-Garcia Ana I, Cruz Miguel, Meyre David
Clinical Epidemiology & Biostatistics, McMaster University , Hamilton , Canada.
Medical Research Unit in Biochemistry, Hospital de Especialidades, Centro Médico Nacional Siglo XXI del Instituto Mexicano del Seguro Social , Mexico City , Mexico.
PeerJ. 2016 Jun 23;4:e2090. doi: 10.7717/peerj.2090. eCollection 2016.
Low-grade chronic inflammation is a common feature of obesity and its cardio-metabolic complications. However, little is known about a possible causal role of inflammation in metabolic disorders. Mexico is among the countries with the highest obesity rates in the world and the admixed Mexican population is a relevant sample due to high levels of genetic diversity.
Here, we studied 1,462 Mexican children recruited from Mexico City. Six genetic variants in five inflammation-related genes were genotyped: rs1137101 (leptin receptor (LEPR)), rs7305618 (hepatocyte nuclear factor 1 alpha (HNF1A)), rs1800629 (tumor necrosis factor alpha (TNFA)), rs1800896, rs1800871 (interleukin-10 (IL-10)), rs1862513 (resistin (RETN)). Ten continuous and eight binary traits were assessed. Linear and logistic regression models were used adjusting for age, sex, and recruitment centre.
We found that one SNP displayed a nominal evidence of association with a continuous trait: rs1800871 (IL-10) with LDL (beta = -0.068 ± 1.006, P = 0.01). Subsequently, we found one nominal association with a binary trait: rs7305618 (HNF1A) with family history of hypertension (odds-ratio = 1.389 [1.054-1.829], P = 0.02). However, no P-value passed the Bonferroni correction for multiple testing.
Our data in a Mexican children population are consistent with previous reports in European adults in failing to demonstrate an association between inflammation-associated single nucleotide polymorphisms (SNPs) and metabolic traits.
低度慢性炎症是肥胖及其心血管代谢并发症的常见特征。然而，关于炎症在代谢紊乱中可能的因果作用知之甚少。墨西哥是世界上肥胖率最高的国家之一，由于高度的遗传多样性，混血的墨西哥人群是一个相关样本。
在此，我们研究了从墨西哥城招募的1462名墨西哥儿童。对五个炎症相关基因中的六个基因变体进行基因分型：rs1137101（瘦素受体（LEPR））、rs7305618（肝细胞核因子1α（HNF1A））、rs1800629（肿瘤坏死因子α（TNFA））、rs1800896、rs1800871（白细胞介素-10（IL-10））、rs1862513（抵抗素（RETN））。评估了十个连续性和八个二元性状。使用线性和逻辑回归模型，并对年龄、性别和招募中心进行了校正。
我们发现一个单核苷酸多态性（SNP）显示出与一个连续性性状存在名义上的关联证据：rs1800871（IL-10）与低密度脂蛋白（β = -0.068 ± 1.006，P = 0.01）。随后，我们发现一个与二元性状存在名义上的关联：rs7305618（HNF1A）与高血压家族史（优势比 = 1.389 [1.054 - 1.829]，P = 0.02）。然而，没有P值通过多重检验的Bonferroni校正。
我们在墨西哥儿童人群中的数据与欧洲成年人先前的报告一致，未能证明炎症相关的单核苷酸多态性（SNP）与代谢性状之间存在关联。
