Siddiqui Atif S, Zimmerman Janice L
Division of Pulmonary and Critical Care, Houston Methodist Hospital, 6565 Fannin St, Houston, TX 77030, USA.
Division of Critical Care, Houston Methodist Hospital, 6565 Fannin St, Houston, TX 77030, USA.
Respir Med Case Rep. 2016 Jun 14;19:15-7. doi: 10.1016/j.rmcr.2016.06.004. eCollection 2016.
Drug-induced interstitial lung disease is associated with significant morbidity and mortality. Everolimus is an inhibitor of mTOR, a mammalian target of rapamycin, used as an immunosuppressant agent in solid organ transplant. Everolimus has been associated with interstitial lung disease in solid organ transplant patients but has been rarely reported in the liver transplant patient population. We report a case of interstitial pneumonitis in a liver transplant patient associated with everolimus which completely resolved after discontinuation of the medication.
药物性间质性肺病与显著的发病率和死亡率相关。依维莫司是一种雷帕霉素哺乳动物靶点（mTOR）的抑制剂，在实体器官移植中用作免疫抑制剂。依维莫司已被证实与实体器官移植患者的间质性肺病有关，但在肝移植患者群体中鲜有报道。我们报告了一例肝移植患者发生的与依维莫司相关的间质性肺炎，在停用该药物后完全缓解。
