肾α-闰细胞、中性粒细胞明胶酶相关脂质运载蛋白与尿路感染
Kidney α-Intercalated Cells, NGAL and Urinary Tract Infection.
作者信息
Chen Lihe, Zhang Wenzheng
机构信息
Graduate School of Biomedical Sciences, University of Texas Health Science Center, USA.
Graduate School of Biomedical Sciences, University of Texas Health Science Center, USA; Department of Internal Medicine, University of Texas Medical School, USA.
出版信息
Austin J Nephrol Hypertens. 2014;1(4). Epub 2014 Oct 10.
It is well known that kidney α-intercalated cells can acidify the urine and acidified urine can inhibit bacterial growth and other urinary organisms. However, regulation of acid-base balance rather than a dedicated function in preventing urinary tract infection has been assigned to α-intercalated cells. A series of studies, culminated by the publication of a paper (J Clin Invest. 2014 Jul 1;124(7):2963-76) from Dr. Barasch's lab unearthed a novel mechanism by which α-intercalated cells function in the innate immune defense of urinary tract infection. This mechanism involves production and release of neutrophil gelatinase-associated lipocalin by α-intercalated cells to chelate the siderophore containing host iron to achieve bacteriostasis.
众所周知，肾脏α-闰细胞可使尿液酸化，而酸化的尿液能够抑制细菌及其他泌尿微生物的生长。然而，α-闰细胞的功能主要是调节酸碱平衡，而非专门用于预防尿路感染。巴拉施博士实验室发表的一篇论文（《临床研究杂志》，2014年7月1日；124(7):2963 - 2976）汇总了一系列研究，揭示了α-闰细胞在尿路感染固有免疫防御中发挥作用的一种新机制。该机制涉及α-闰细胞产生并释放中性粒细胞明胶酶相关脂质运载蛋白，以螯合含有宿主铁的铁载体，从而实现抑菌作用。
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