Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology , 4, Raja S. C. Mullick Road, Kolkata 700032, India.
Academy of Scientific and Innovative Research (AcSIR) , 4, Raja S. C. Mullick Road, Kolkata 700032, India.
Org Lett. 2016 Jul 15;18(14):3394-7. doi: 10.1021/acs.orglett.6b01554. Epub 2016 Jul 1.
The synthesis of a 3-fold symmetric cofacial organic cage (COC) through Cu(I)-catalyzed azide-alkyne cycloaddition is reported. The COC can function as an efficient receptor for carcinogenic polycyclic aromatic hydrocarbons to intercalate them in its intrinsic cavity through donor-acceptor and π···π stacking interactions. The association constants (Ka) are in the range of 3.7 × 10(4) to 1.3 × 10(6) M(-1). X-ray diffraction analysis authenticated that the polycyclic aromatic hydrocarbons (PAHs) are intercalated in the interior of the COC.
通过铜（I）催化的叠氮化物-炔烃环加成反应，合成了一种 3 重对称共面有机笼（COC）。该 COC 可以作为一种有效的致癌多环芳烃受体，通过供体-受体和 π···π 堆积相互作用将其插入其固有腔中。结合常数（Ka）在 3.7×10(4)至 1.3×10(6) M(-1)范围内。X 射线衍射分析证实多环芳烃（PAHs）插入 COC 的内部。
