Zhao Donghai, Zheng Lianwen, Qi Ling, Wang Shuran, Guan Liping, Xia Yanan, Cai Jianhui
The Basic Medical College, Jilin Medical University, Jilin 132013, China.
The Second Hospital, Jilin University, Changchun 130041, China.
Mar Drugs. 2016 Jun 28;14(7):123. doi: 10.3390/md14070123.
The purified total sterols and β-sitosterol extracted from Sargassum horneri were evaluated for their antidepressant-like activity using the forced swim test (FST) and tail suspension test (TST) in mice. Total sterols and β-sitosterol significantly reduced the immobility time in the FST and TST. Total sterols were administered orally for 7 days at doses of 50, 100, and 200 mg/kg, and β-sitosterol was administered intraperitoneally at doses of 10, 20, and 30 mg/kg. β-sitosterol had no effect on locomotor activity in the open field test. In addition, total sterols and β-sitosterol significantly increased NE, 5-HT, and the metabolite 5-HIAA in the mouse brain, suggesting that the antidepressant-like activity may be mediated through these neurotransmitters.
利用强迫游泳试验（FST）和悬尾试验（TST），对从鼠尾藻中提取的纯化总甾醇和β-谷甾醇的抗抑郁样活性进行了评估。总甾醇和β-谷甾醇显著缩短了FST和TST中的不动时间。总甾醇以50、100和200mg/kg的剂量口服给药7天，β-谷甾醇以10、20和30mg/kg的剂量腹腔注射给药。β-谷甾醇在旷场试验中对运动活性没有影响。此外，总甾醇和β-谷甾醇显著增加了小鼠脑中的去甲肾上腺素（NE）、5-羟色胺（5-HT）及其代谢产物5-羟吲哚乙酸（5-HIAA），这表明抗抑郁样活性可能是通过这些神经递质介导的。
