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谁在调控谁？RNA 颗粒与病毒感染概述。

Who Regulates Whom? An Overview of RNA Granules and Viral Infections.

作者信息

Poblete-Durán Natalia, Prades-Pérez Yara, Vera-Otarola Jorge, Soto-Rifo Ricardo, Valiente-Echeverría Fernando

机构信息

Molecular and Cellular Virology Laboratory, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Independencia 1027, Santiago, 8389100, Chile.

Laboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Centro de Investigaciones Médicas, Departamento de Enfermedades Infecciosas e Inmunología Pediátrica, Escuela de Medicina, Pontificia Universidad Católica de Chile, Marcoleta 391, Santiago 8330024, Chile.

出版信息

Viruses. 2016 Jun 28;8(7):180. doi: 10.3390/v8070180.

DOI:10.3390/v8070180
PMID:27367717
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4974515/
Abstract

After viral infection, host cells respond by mounting an anti-viral stress response in order to create a hostile atmosphere for viral replication, leading to the shut-off of mRNA translation (protein synthesis) and the assembly of RNA granules. Two of these RNA granules have been well characterized in yeast and mammalian cells, stress granules (SGs), which are translationally silent sites of RNA triage and processing bodies (PBs), which are involved in mRNA degradation. This review discusses the role of these RNA granules in the evasion of anti-viral stress responses through virus-induced remodeling of cellular ribonucleoproteins (RNPs).

摘要

病毒感染后，宿主细胞通过启动抗病毒应激反应做出响应，以营造不利于病毒复制的环境，导致mRNA翻译（蛋白质合成）停止和RNA颗粒的组装。其中两种RNA颗粒在酵母和哺乳动物细胞中已得到充分表征，即应激颗粒（SGs），它是RNA分类的翻译沉默位点，以及加工小体（PBs），它参与mRNA降解。本文综述了这些RNA颗粒在病毒诱导的细胞核糖核蛋白（RNP）重塑以逃避抗病毒应激反应中的作用。

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Ebola Virus Does Not Induce Stress Granule Formation during Infection and Sequesters Stress Granule Proteins within Viral Inclusions.埃博拉病毒在感染过程中不诱导应激颗粒形成，并将应激颗粒蛋白隔离在病毒包涵体内。
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The Herpes Simplex Virus Virion Host Shutoff Protein Enhances Translation of Viral True Late mRNAs Independently of Suppressing Protein Kinase R and Stress Granule Formation.单纯疱疹病毒病毒体宿主关闭蛋白独立于抑制蛋白激酶R和应激颗粒形成增强病毒真正晚期mRNA的翻译。
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HIV-1 Gag Blocks Selenite-Induced Stress Granule Assembly by Altering the mRNA Cap-Binding Complex.HIV-1核衣壳蛋白通过改变mRNA帽结合复合体来阻断亚硒酸盐诱导的应激颗粒组装。
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