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公开报告是否会影响针对所有患者的抗生素和注射剂处方?一项在中国进行的整群随机配对试验。

Does public reporting influence antibiotic and injection prescribing to all patients? A cluster-randomized matched-pair trial in china.

作者信息

Liu Chenxi, Zhang Xinping, Wang Xuan, Zhang Xiaopeng, Wan Jie, Zhong Fangying

机构信息

School of Medicine and Health Management, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

出版信息

Medicine (Baltimore). 2016 Jun;95(26):e3965. doi: 10.1097/MD.0000000000003965.

Abstract

The inappropriate use and overuse of antibiotics and injections are serious threats to global population, and the public reporting of health care performance (PRHCP) has been an important instrument for improving the quality of care. However, existing evidence shows a mixed effect of PRHCP. This study is to explore the potential effectiveness of PRHCP that contributes to the convincing evidence of health policy and reform.This study was undertaken in Qian Jiang City, applying a matched-pair cluster-randomized trial. Twenty primary care institutions were treated as clusters and were matched into 10 pairs. Clusters in each pair were randomly assigned into a control or an intervention group. Physicians' prescribing information was publicly reported to patients and physicians monthly in the intervention group from October 2013. A total of 748,632 outpatient prescriptions were included for difference-in-difference (DID) regression model and subgroups (SGs) analysis.Overall, PRHCP intervention led to a slight reduction in the use of combined antibiotics (odds ratio [OR] = 0.870, P < 0.001) and slowed the average expenditure increase of patients (coefficient = -0.051, P < 0.001). SG analysis showed the effect of PRHCP varied among patients with different characteristics. PRHCP decreased the probability of prescriptions requiring antibiotics, combined antibiotics, and injections of patients aged 18 to 64 years old (OR < 1), and all results were statistically significant. By contrast, the results of elderly and minor patients with health insurance showed that PRHCP increased their probability of prescriptions requiring antibiotics and injections. PRHCP slowed the increase of average expenditure of most SGs.PRHCP intervention can influence the prescribing pattern of physicians. Patient factors such as age and health insurance influence the effect of PRHCP intervention, which imply that PRHCP should be designed for different patients. Patient education, aiming at radically changing attitudes toward antibiotics and injections, should be taken to promote the effectiveness of public reporting in China.

摘要

抗生素和注射剂的不当使用与过度使用对全球人口构成严重威胁,而医疗保健绩效的公开报告(PRHCP)一直是提高医疗质量的重要手段。然而,现有证据表明PRHCP的效果参差不齐。本研究旨在探讨PRHCP的潜在有效性,为卫生政策和改革提供有说服力的证据。本研究在潜江市开展,采用配对整群随机试验。将20个基层医疗机构作为整群,并配对成10对。每对中的整群随机分为对照组或干预组。从2013年10月起,干预组每月向患者和医生公开报告医生的处方信息。共纳入748632张门诊处方用于差分(DID)回归模型和亚组(SGs)分析。总体而言,PRHCP干预使联合使用抗生素的情况略有减少(优势比[OR]=0.870,P<0.001),并减缓了患者平均支出的增长(系数=-0.051,P<0.001)。SG分析表明,PRHCP的效果在不同特征的患者中有所不同。PRHCP降低了18至64岁患者开具抗生素、联合使用抗生素和注射剂处方的概率(OR<1),所有结果均具有统计学意义。相比之下,有医疗保险的老年患者和未成年患者的结果显示,PRHCP增加了他们开具抗生素和注射剂处方的概率。PRHCP减缓了大多数亚组平均支出的增长。PRHCP干预可以影响医生的处方模式。年龄和医疗保险等患者因素会影响PRHCP干预的效果,这意味着应针对不同患者设计PRHCP。应开展旨在从根本上改变对抗生素和注射剂态度的患者教育,以提高中国公开报告的有效性。

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Public reporting influences antibiotic and injection prescription in primary care: a segmented regression analysis.
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