Amundstuen Reppe Linda, Lydersen Stian, Schjøtt Jan, Damkier Per, Rolighed Christensen Hanne, Peter Kampmann Jens, Böttiger Ylva, Spigset Olav
Faculty of Health Sciences, Nord University, Steinkjer, Norway; Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway; Regional Medicines Information and Pharmacovigilance Center (Midt-Norge), St. Olavs Hospital, Trondheim, Norway.
Regional Center for Child and Youth Mental Health and Child Welfare-Central Norway, Norwegian University of Science and Technology, Trondheim, Norway.
Clin Ther. 2016 Jul;38(7):1738-49. doi: 10.1016/j.clinthera.2016.05.010. Epub 2016 Jun 29.
The aims of this study were to assess the quality of responses produced by drug information centers (DICs) in Scandinavia, and to study the association between time consumption processing queries and the quality of the responses.
We posed six identical drug-related queries to seven DICs in Scandinavia, and the time consumption required for processing them was estimated. Clinical pharmacologists (internal experts) and general practitioners (external experts) reviewed responses individually. We used mixed model linear regression analyses to study the associations between time consumption on one hand and the summarized quality scores and the overall impression of the responses on the other hand.
Both expert groups generally assessed the quality of the responses as "satisfactory" to "good." A few responses were criticized for being poorly synthesized and less relevant, of which none were quality-assured using co-signatures. For external experts, an increase in time consumption was statistically significantly associated with a decrease in common quality score (change in score, -0.20 per hour of work; 95% CI, -0.33 to -0.06; P = 0.004), and overall impression (change in score, -0.05 per hour of work; 95% CI, -0.08 to -0.01; P = 0.005). No such associations were found for the internal experts' assessment.
To our knowledge, this is the first study of the association between time consumption and quality of responses to drug-related queries in DICs. The quality of responses were in general good, but time consumption and quality were only weakly associated in this setting.
本研究旨在评估斯堪的纳维亚地区药物信息中心（DICs）给出的回复质量，并研究处理问题所耗费的时间与回复质量之间的关联。
我们向斯堪的纳维亚地区的七个DICs提出了六个相同的与药物相关的问题，并估算了处理这些问题所需的时间。临床药理学家（内部专家）和全科医生（外部专家）分别对回复进行评审。我们使用混合模型线性回归分析来研究一方面处理时间与另一方面汇总质量得分和回复总体印象之间的关联。
两个专家小组总体上都将回复质量评定为“满意”至“良好”。一些回复因综合度差和相关性低而受到批评，其中没有一个通过共同署名进行质量保证。对于外部专家而言，处理时间的增加与共同质量得分的降低在统计学上显著相关（得分变化，每工作一小时 -0.20；95%置信区间，-0.33至 -0.06；P = 0.004），以及总体印象（得分变化，每工作一小时 -0.05；95%置信区间，-0.08至 -0.01；P = 0.005）。在内部专家的评估中未发现此类关联。
据我们所知，这是第一项关于DICs中处理与药物相关问题的时间消耗与回复质量之间关联的研究。回复质量总体良好，但在这种情况下，时间消耗与质量之间的关联较弱。
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