Doss Grayson A, Mans Christoph, Stepien Rebecca L
1 Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Wisconsin, USA.
2 Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Wisconsin, USA.
Lab Anim. 2017 Feb;51(1):89-92. doi: 10.1177/0023677216658079. Epub 2016 Jul 9.
Alpha-agonist anesthetic combinations are often used in rodent anesthesia but no information about their effects on cardiac function in chinchillas exists. The purpose of this study was to utilize echocardiography to evaluate the cardiovascular effects of dexmedetomidine-ketamine anesthesia in chinchillas. Echocardiographic examinations were performed in eight adult chinchillas under manual restraint and following dexmedetomidine (0.015 mg/kg) and ketamine (4 mg/kg) administration. Dexmedetomidine-ketamine anesthesia resulted in a significantly decreased heart rate, fractional shortening, cardiac output, and flow velocity across the aortic and pulmonic valves, and significantly increased left ventricular internal diameter in systole. The observed changes in echocardiographic parameters are similar to those previously reported in chinchillas anesthetized with isoflurane.
α-激动剂麻醉组合常用于啮齿动物麻醉，但目前尚无关于其对龙猫心脏功能影响的信息。本研究的目的是利用超声心动图评估右美托咪定-氯胺酮麻醉对龙猫心血管系统的影响。在8只成年龙猫处于人工约束状态下，以及给予右美托咪定（0.015mg/kg）和氯胺酮（4mg/kg）后，进行了超声心动图检查。右美托咪定-氯胺酮麻醉导致心率、缩短分数、心输出量以及主动脉瓣和肺动脉瓣处的血流速度显著降低，左心室收缩内径显著增加。超声心动图参数的观察变化与先前报道的用异氟烷麻醉的龙猫相似。
