[新生儿毛细血管血糖浓度与血浆葡萄糖测量的评估]

[Evaluation of the measurement of capillary glucose concentration versus plasma glucose in the newborn].

作者信息

Ben Ameur K, Chioukh F Z, Bouanene I, Ghedira E S, Ben Hamida H, Bizid M, Ben Salem K, Tabka R, Babba H, Monastiri K

机构信息

Service de réanimation et de médecine néonatale, centre de maternité et de néonatalogie, EPS Fattouma Bourguiba, 5000 Monastir, Tunisie; CHU Fattouma Bourguiba, Monastir, faculté de médecine de Monastir, EPS Fattouma Bourguiba, 5000 Monastir, Tunisie.

出版信息

Arch Pediatr. 2016 Sep;23(9):908-12. doi: 10.1016/j.arcped.2016.04.025. Epub 2016 Jun 28.

DOI:10.1016/j.arcped.2016.04.025

PMID:27369101

Abstract

BACKGROUND

The reliability of blood glucose monitoring in neonatology is not always confirmed. The aim of this study was to evaluate the reliability of blood glucose measurements made with three different devices in newborns.

PATIENTS AND METHODS

The study was prospective, conducted in a medical and neonatal intensive care department over a period of 4 months. Capillary glucose level was measured with three different glucometers and compared with venous glucose level determined using the hexokinase method. An ANOVA and Scheffe test were used for the correlation analysis.

RESULTS

Three hundred and nine infants were included, with a mean age of 55h and a mean term of 39 weeks of gestation. Mean blood glucose in the laboratory was 0.62±0.15g/L, 0.71±0.17g/L for Accu-Chek(®) Active, 0.80±0.17g/L for Accu-Chek(®) Performa, and 0.83±0.12g/L for Bionime. An ANOVA showed statistically significant differences between the measurements made by glucometers compared to the reference blood glucose levels, and the Scheffé method showed that glucometers overestimated the real plasma glucose levels.

CONCLUSION

None of the devices used in this study was satisfactory. However, an estimation of blood glucose taking into consideration this numerical overestimation would allow early detection of hypoglycemia.

摘要

背景

新生儿科血糖监测的可靠性并非总能得到证实。本研究的目的是评估三种不同设备在新生儿中进行血糖测量的可靠性。

患者与方法

本研究为前瞻性研究，在一个内科及新生儿重症监护病房进行，为期4个月。使用三种不同的血糖仪测量毛细血管血糖水平，并与采用己糖激酶法测定的静脉血糖水平进行比较。采用方差分析和谢费检验进行相关性分析。

结果

纳入309例婴儿，平均年龄55小时，平均孕周39周。实验室测得的平均血糖为0.62±0.15g/L，罗氏卓越型血糖仪测得的血糖为0.71±0.17g/L，罗氏优越型血糖仪测得的血糖为0.80±0.17g/L，台湾必优尼血糖仪测得的血糖为0.83±0.12g/L。方差分析显示，与参考血糖水平相比，血糖仪测量结果存在统计学显著差异，谢费检验表明血糖仪高估了实际血浆葡萄糖水平。