Lu Z L, Zhang G X, Liu W
Zhonghua Nei Ke Za Zhi. 1989 Jan;28(1):28-31, 62.
Evaluation of the clinical and biochemical parameters for differential diagnosis of two types of Cushing's syndrome, pituitary-dependent Cushing's disease and adrenal adenoma, was studied with analysis of the histories of 79 cases of Cushing's disease and 23 cases of adrenal adenoma. The data show that the symptoms, signs and the routine biochemical analyses were not significantly different between two groups. High-dose dexamethasone suppression test had about 90% coincidence rate in the differential diagnosis with 24-hour urine free cortisol (UFC), which was better than 24-hour urine 17-OHCS. Interestingly, low-dose dexamethasone test was highly valuable and the 24-hour urine 17-KS quite helpful in the differential diagnosis of two types of Cushing's syndrome. Serum N-POMC measurement was the most valuable among the parameters, because there was no overlap between the two groups of Cushing's syndrome.
通过分析79例库欣病患者和23例肾上腺腺瘤患者的病史，对用于鉴别诊断两种类型库欣综合征（垂体依赖性库欣病和肾上腺腺瘤）的临床和生化参数进行了研究。数据显示，两组之间的症状、体征和常规生化分析无显著差异。高剂量地塞米松抑制试验与24小时尿游离皮质醇（UFC）在鉴别诊断中的符合率约为90%，优于24小时尿17-羟皮质类固醇。有趣的是，低剂量地塞米松试验具有很高的价值，24小时尿17-酮类固醇对两种类型库欣综合征的鉴别诊断也很有帮助。血清N-POMC测定在这些参数中最有价值，因为两组库欣综合征之间没有重叠。
