Ancheva M, Boeva M, Tenev V
Eksp Onkol. 1989;11(2):39-41.
The NK activity was studied in 15 male patients with stage III of the lung cancer. All patients underwent operation. The NK activity was tested against H3 uridine-labeled K-562 tumour cells in the 4-hour cytotoxic test before and 8-14 days after the surgery. As control 15 healthy men were tested. The NK activity of mononuclear cells of the peripheral blood and nonadherent lymphocytes in the lung cancer patients before surgery was significantly decreased (P less than 0.001). Surgery did not affect essentially the NK activity. The removal of monocytes from the mononuclear cell suspension of the peripheral blood caused enhancement of the NK activity only in the postoperative period (P less than 0.05). Survival of the patients did not correlate with the cytotoxic activity of the NK cells before (r = 0.071) and after surgery (r = 0.275). The postoperative cytotoxic activity of NK cells correlated better with survival of the patients.
对15例Ⅲ期肺癌男性患者的自然杀伤细胞（NK）活性进行了研究。所有患者均接受了手术。在手术前及术后8 - 14天的4小时细胞毒性试验中，以H3尿苷标记的K - 562肿瘤细胞检测NK活性。作为对照，对15名健康男性进行了检测。肺癌患者术前外周血单个核细胞和非黏附淋巴细胞的NK活性显著降低（P＜0.001）。手术对NK活性基本无影响。从外周血单个核细胞悬液中去除单核细胞仅在术后增强了NK活性（P＜0.05）。患者的生存期与术前（r = 0.071）及术后（r = 0.275）NK细胞的细胞毒性活性均无相关性。NK细胞的术后细胞毒性活性与患者的生存期相关性更好。
