L-半胱氨酸抑制的丙酮酸激酶作为致瘤性人膀胱上皮细胞系的标志物
Pyruvate kinase inhibited by L-cysteine as a marker of tumorigenic human urothelial cell lines.
作者信息
Gumińska M, Stachurska M B, Christensen B, Tromholt V, Kieler J, Radzikowski C, Duś D
机构信息
Institute of Medical Biochemistry, N. Copernicus Academy of Medicine, Kraków, Poland.
出版信息
Experientia. 1989 Jun 15;45(6):571-4. doi: 10.1007/BF01990510.
PMID:2737264
Abstract
It was found that a decrease in electrophoretic mobility of pyruvate kinase (PK) isoenzyme, and an increase of the sensitivity of this enzyme to L-cysteine, were markers of immortalization and tumorigenic properties, respectively, in human urothelial cell lines characterized by different grades of transformation (TGr) in vitro.
摘要
结果发现，在体外具有不同转化程度（TGr）特征的人尿道上皮细胞系中，丙酮酸激酶（PK）同工酶的电泳迁移率降低以及该酶对L-半胱氨酸的敏感性增加，分别是永生化和致瘤特性的标志物。
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