Synthesis of O1.5-(beta-D-galactopyranosyl) [DMet2, Hyp5] enkephalin amide, a new highly potent analgesic enkephalin-related glycosyl peptide.
作者信息
Torres J L, Haro I, Valencia G, Reig F, García-Antón J M
机构信息
Peptide Research Section, Centre d'Investigació i Desenvolupament, C.S.I.C., Barcelona, Spain.
出版信息
Experientia. 1989 Jun 15;45(6):574-6. doi: 10.1007/BF01990511.
PMID:2737265
Abstract
A new series of O-glycosyl enkephalins has been prepared, following a convergent strategy, with high chemical yields. The galactosyl analogue, O1.5-(beta-D-galactopyranosyl) [DMet2, Hyp5] enkephalin amide proved to be one of the most potent in vivo opioid agonists synthesized up to now.
摘要
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