Jakse G, Putz A, Feichtinger J
Department of Urology, University of Innsbruck, Austria.
Eur J Surg Oncol. 1989 Jun;15(3):211-6.
Patients (n = 46) with carcinoma in situ (Tis) of the urinary bladder were treated by intravesical chemotherapy. The complete remission rate was 75%. After a mean interval of 17 months recurrent tumours were diagnosed in 47%. Radical cystectomy with urethrectomy was performed in eight patients. Distal ureterectomy and uretercystoneostomy was done in six patients because of a distal ureteric tumour. Based on this group of 46 patients and the current literature, the following criteria are essential in indicating cystectomy: (1) micro-invasion; (2) persistent Tis after adequate intravesical treatment; (3) progressive tumour; (4) Tis of ureter and/or prostate; (5) tumour recurrence at more advanced stage.
46例膀胱原位癌（Tis）患者接受了膀胱内化疗。完全缓解率为75%。平均间隔17个月后，47%的患者被诊断出肿瘤复发。8例患者接受了根治性膀胱切除术加尿道切除术。6例患者因输尿管远端肿瘤行远端输尿管切除术和输尿管膀胱吻合术。基于这组46例患者及当前文献，以下标准对于指示膀胱切除术至关重要：（1）微浸润；（2）充分膀胱内治疗后Tis持续存在；（3）肿瘤进展；（4）输尿管和/或前列腺Tis；（5）更晚期的肿瘤复发。
