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撤回:对瑞典有先天性肾上腺皮质增生症风险的青少年进行产前地塞米松治疗后行为问题的评估。

RETRACTED: Evaluation of behavioral problems after prenatal dexamethasone treatment in Swedish adolescents at risk of CAH.

作者信息

Wallensteen Lena, Zimmermann Marius, Sandberg Malin Thomsen, Gezelius Anton, Nordenström Anna, Hirvikoski Tatja, Lajic Svetlana

机构信息

Department of Women's and Children's Health, Karolinska Institutet, Pediatric Endocrinology Unit (Q2:08), Karolinska University Hospital, SE-171 76 Stockholm, Sweden.

Department of Women's and Children's Health, KIND, Karolinska Institutet, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.

出版信息

Horm Behav. 2016 Sep;85:5-11. doi: 10.1016/j.yhbeh.2016.06.011. Epub 2016 Jun 30.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the authors due to technical errors that have called into question the reliability of the data used to inform the author's conclusions. All data on cognitive and behavioral outcomes in CAH and non–CAH cases, treated or not treated with DEX prenatally, were put into a single Excel database. The authors had in total four different patient groups for each age group (5–6 y, 7–17 y and 18-35 y). The database consisted of 237 cases in total and there were multiple columns for the different outcome measures. When the behavioral data for the sub-cohort described in this paper (first trimester treated non-CAH cases and healthy population controls, age 7–17 y) were copied to another sheet and compressed/modified in preparation for statistical analysis in SPSS, an error occurred. This technological issue caused rows to shift and the data from the different groups got mixed up. In particular, the non–CAH group versus the control group were "contaminated" with cases from the wrong patient group. The authors discovered this mistake when they started to analyse the data from the other sub–groups of patients, the CAH cases and the adult cohort, which was after their original results had already been published in Hormones and Behavior in this manuscript "Evaluation of behavioral problems after prenatal dexamethasone treatment in Swedish adolescents at risk of CAH". It then became apparent that the entire data set was unreliable and needed to be re–analysed which is what has motivated the retraction of this article. The authors have recently completed this re–analysis and the results have been published here: https://www.sciencedirect.com/science/article/pii/S0018506X17300752

摘要

本文已被撤回

请参阅爱思唯尔的文章撤回政策(http://www.elsevier.com/locate/withdrawalpolicy)。由于技术错误,本文应作者要求被撤回,这些错误使用于支持作者结论的数据的可靠性受到质疑。所有关于先天性肾上腺皮质增生症(CAH)和非CAH病例(无论产前是否接受地塞米松治疗)的认知和行为结果的数据都被录入到一个单一的Excel数据库中。作者针对每个年龄组(5 - 6岁、7 - 17岁和18 - 35岁)共有四个不同的患者组。该数据库总共包含237个病例,并且针对不同的结果测量有多个列。当将本文中描述的亚组(孕早期接受治疗的非CAH病例和健康人群对照,年龄7 - 17岁)的行为数据复制到另一工作表并进行压缩/修改以准备在SPSS中进行统计分析时,发生了一个错误。这个技术问题导致行发生偏移,不同组的数据混淆在一起。特别是,非CAH组与对照组被来自错误患者组的病例“污染”。作者在开始分析其他患者亚组(CAH病例和成人队列)的数据时发现了这个错误,而此时他们的原始结果已经在《激素与行为》杂志上发表,该手稿标题为“瑞典有CAH风险的青少年产前地塞米松治疗后行为问题的评估”。随后很明显整个数据集不可靠,需要重新分析,这就是促使撤回本文的原因。作者最近完成了这项重新分析,结果已在此处发表:https://www.sciencedirect.com/science/article/pii/S0018506X17300752

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