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用于脑肿瘤治疗中细胞内蛋白质递送的可调谐脂质体-末端树枝状聚合物杂化纳米颗粒

Tunable Lipidoid-Telodendrimer Hybrid Nanoparticles for Intracellular Protein Delivery in Brain Tumor Treatment.

作者信息

Wang Xu, Bodman Alexa, Shi Changying, Guo Dandan, Wang Lili, Luo Juntao, Hall Walter A

机构信息

Department of Pharmacology, Upstate Cancer Center, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.

Department of Neurosurgery, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.

出版信息

Small. 2016 Aug;12(31):4185-92. doi: 10.1002/smll.201601234. Epub 2016 Jul 4.

DOI:10.1002/smll.201601234
PMID:27375237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4982832/
Abstract

A strategy to precisely engineer lipidoid-telodendrimer binary hybrid nanoparticles that offer enhanced cell membrane permeability for therapeutic proteins to reach the intracellular targets is established. The highly controllable biochemical and physical properties of the nanoparticles make them promising for protein-based brain cancer treatment with the assistance of convection-enhanced delivery.

摘要

建立了一种精确设计脂质体 - 端基树枝状大分子二元杂化纳米颗粒的策略，该纳米颗粒可增强细胞膜通透性，使治疗性蛋白质能够到达细胞内靶点。纳米颗粒高度可控的生化和物理性质使其在对流增强递送的辅助下，有望用于基于蛋白质的脑癌治疗。

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本文引用的文献

1
Mutagenic Deimmunization of Diphtheria Toxin for Use in Biologic Drug Development.用于生物药物开发的白喉毒素诱变去免疫化
Toxins (Basel). 2015 Oct 10;7(10):4067-82. doi: 10.3390/toxins7104067.
2
A drug-specific nanocarrier design for efficient anticancer therapy.一种用于高效抗癌治疗的药物特异性纳米载体设计。
Nat Commun. 2015 Jul 9;6:7449. doi: 10.1038/ncomms8449.
3
Bioinspired therapeutic dendrimers as efficient peptide drugs based on supramolecular interactions for tumor inhibition.基于超分子相互作用的仿生治疗树枝状聚合物作为有效的肽类药物用于肿瘤抑制。
Angew Chem Int Ed Engl. 2015 Mar 27;54(14):4289-94. doi: 10.1002/anie.201500683. Epub 2015 Feb 26.
4
Fine-tuning vitamin E-containing telodendrimers for efficient delivery of gambogic acid in colon cancer treatment.微调含维生素E的端粒树枝状大分子以实现藤黄酸在结肠癌治疗中的高效递送。
Mol Pharm. 2015 Apr 6;12(4):1216-29. doi: 10.1021/acs.molpharmaceut.5b00051. Epub 2015 Mar 2.
5
Noncanonical amino acids to improve the pH response of pHLIP insertion at tumor acidity.非标准氨基酸用于改善肿瘤酸性环境下pHLIP插入的pH响应。
Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3658-3663. doi: 10.1002/anie.201409770. Epub 2015 Feb 4.
6
A multitheragnostic nanobubble system to induce blood-brain barrier disruption with magnetically guided focused ultrasound.一种多诊断纳米气泡系统，通过磁引导聚焦超声诱导血脑屏障破坏。
Adv Mater. 2015 Jan 27;27(4):655-61. doi: 10.1002/adma.201403889. Epub 2014 Dec 3.
7
Telodendrimer nanocarrier for co-delivery of paclitaxel and cisplatin: A synergistic combination nanotherapy for ovarian cancer treatment.用于共递送紫杉醇和顺铂的末端树枝状聚合物纳米载体：一种用于卵巢癌治疗的协同联合纳米疗法。
Biomaterials. 2015 Jan;37:456-468. doi: 10.1016/j.biomaterials.2014.10.044. Epub 2014 Oct 31.
8
Functional supramolecular polymers for biomedical applications.用于生物医学应用的功能超分子聚合物。
Adv Mater. 2015 Jan 21;27(3):498-526. doi: 10.1002/adma.201402975. Epub 2014 Nov 12.
9
Development of multinuclear polymeric nanoparticles as robust protein nanocarriers.多核聚合物纳米颗粒作为坚固蛋白质纳米载体的开发。
Angew Chem Int Ed Engl. 2014 Aug 18;53(34):8975-9. doi: 10.1002/anie.201404766. Epub 2014 Jul 2.
10
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity.具有可预测体内siRNA递送活性的可降解脂质纳米颗粒。
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