用于脑肿瘤治疗中细胞内蛋白质递送的可调谐脂质体-末端树枝状聚合物杂化纳米颗粒
Tunable Lipidoid-Telodendrimer Hybrid Nanoparticles for Intracellular Protein Delivery in Brain Tumor Treatment.
作者信息
Wang Xu, Bodman Alexa, Shi Changying, Guo Dandan, Wang Lili, Luo Juntao, Hall Walter A
机构信息
Department of Pharmacology, Upstate Cancer Center, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.
Department of Neurosurgery, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.
出版信息
Small. 2016 Aug;12(31):4185-92. doi: 10.1002/smll.201601234. Epub 2016 Jul 4.
Abstract
A strategy to precisely engineer lipidoid-telodendrimer binary hybrid nanoparticles that offer enhanced cell membrane permeability for therapeutic proteins to reach the intracellular targets is established. The highly controllable biochemical and physical properties of the nanoparticles make them promising for protein-based brain cancer treatment with the assistance of convection-enhanced delivery.
摘要
建立了一种精确设计脂质体 - 端基树枝状大分子二元杂化纳米颗粒的策略，该纳米颗粒可增强细胞膜通透性，使治疗性蛋白质能够到达细胞内靶点。纳米颗粒高度可控的生化和物理性质使其在对流增强递送的辅助下，有望用于基于蛋白质的脑癌治疗。
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