In 't Hout B A, Schenk K E, van der Linden A N, Roumen R M H
Department of Surgery, Máxima Medical Centre, P.O. Box 7777, 5500 MB Veldhoven, The Netherlands.
Department of Surgery, Máxima Medical Centre, P.O. Box 7777, 5500 MB Veldhoven, The Netherlands.
Breast. 2016 Oct;29:8-13. doi: 10.1016/j.breast.2016.06.011. Epub 2016 Jul 1.
To achieve radical tumour excision in non-palpable breast cancer accurate tumour localization is essential. Historically, this has been achieved by wire localization (WL). Recently, new techniques like Iodine-125 seeds (IL) have become available. The aim of this study was to determine whether the results in case of IL are better than when WL is used.
A consecutive series of patients operated on because of non-palpable breast cancer was analysed. Between January 2007 and April 2011 WL was method of choice. From April 2011 till January 2013 IL was introduced and became the standard procedure. PRIMARY OUTCOMES WERE: success rate of (peri-) operative localization and radicality of the excision. Secondary outcomes were duration of operation and volumes of the excised tissue specimen.
A total of 236 women were included; 149 women underwent WL and 87 women IL. The overall success rate for WL was 93.3%. In 10 patients (6.7%) WL failed because of peri-operative dislocation of the wire compared to only one failure to locate the seed in de postoperative specimen in the IL-group (1.1%, p = 0.098). Radical resection was obtained in 126/149 (84.6%) of the WL-patients, in comparison with 81/87 (93.1%) in the IL-group (p = 0.054). Median operation time and volume of the specimen was not significantly different between both groups.
Localization of non-palpable breast cancer using Iodine-125 seeds is, at least, as good as the standard wire localization procedure.
为实现不可触及性乳腺癌的根治性肿瘤切除，准确的肿瘤定位至关重要。从历史上看，这是通过钢丝定位（WL）来实现的。最近，像碘 - 125种子（IL）这样的新技术已经出现。本研究的目的是确定IL的效果是否优于使用WL时的效果。
对一系列因不可触及性乳腺癌而接受手术的患者进行了分析。2007年1月至2011年4月期间，WL是首选方法。从2011年4月到2013年1月引入了IL并成为标准程序。主要结果是：（围）手术期定位成功率和切除的根治性。次要结果是手术持续时间和切除组织标本的体积。
共纳入236名女性；149名女性接受了WL，87名女性接受了IL。WL的总体成功率为93.3%。在10名患者（6.7%）中，WL因围手术期钢丝移位而失败，相比之下，IL组中只有1例在术后标本中未能找到种子（1.1%，p = 0.098）。WL组126/149（84.6%）的患者实现了根治性切除，而IL组为81/87（93.1%）（p = 0.054）。两组之间的中位手术时间和标本体积没有显著差异。
使用碘 - 125种子对不可触及性乳腺癌进行定位，至少与标准的钢丝定位程序一样好。
