Kudish Avraham, Marsakova Anna, Jahn Irmgard, Gkalpakiotis Spyridon, Arenberger Peter, Harari Marco
Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Arava & Dead Sea Science Center, Neve Zohar, Israel.
Photodermatol Photoimmunol Photomed. 2016 Sep;32(5-6):254-261. doi: 10.1111/phpp.12250. Epub 2016 Jul 26.
Atopic dermatitis (AD) is a common, chronic, and relapsing inflammatory skin disorder. Moderate to severe cases represent an extremely disabling disease, for both children and their parents. Dead Sea climatotherapy (DSC), recognized as a natural treatment for patients with skin diseases, takes advantage of the selectively scattered ultraviolet irradiation (UV) present at the lowest terrestrial site on the earth.
To investigate the impact on short-term results of DSC in moderate to severe AD children from the Czech Republic treated 4 weeks at the Deutsches Medizinisches Zentrum (DMZ), Israel, and to correlate their results to the cumulative UVA and UVB irradiation doses received during treatment.
Seventy-two patients aged <19 years were divided into three groups and treated in March 2014, October 2014, and March 2015 with gradually increasing sun exposure during 28 consecutive days. Daily and cumulative exposure doses of UVB and UVA were calculated through patients' recorded sun exposure logs. The SCORing Atopic Dermatitis (SCORAD) index was recorded immediately after DSC and 3 months later by the same dermatologist.
Good clinical results were observed in all groups, with overall improvement in SCORAD reaching 87.5 ± 13.4% and 71.3 ± 21.3% immediately after DSC and 3 months later, respectively. No side effects were observed during the treatments. Higher cumulative exposure times correlated with better results and enhanced remission.
Dead Sea climatotherapy represents a valuable option for the treatment of AD in children. Medically controlled and prescribed sun exposure seems to directly and positively influence the results obtained.
特应性皮炎（AD）是一种常见的、慢性复发性炎症性皮肤病。中重度病例对儿童及其父母来说都是极具致残性的疾病。死海气候疗法（DSC）被认为是一种治疗皮肤病患者的自然疗法，它利用了地球上最低陆地位置存在的选择性散射紫外线辐射（UV）。
研究在以色列的德国医学中心（DMZ）对来自捷克共和国的中重度AD儿童进行4周DSC治疗的短期效果影响，并将其结果与治疗期间接受的累积UVA和UVB辐射剂量相关联。
72名年龄<19岁的患者被分为三组，分别于2014年3月、2014年10月和2015年3月接受治疗，在连续28天内逐渐增加日照时间。通过患者记录的日照日志计算UVB和UVA的每日和累积暴露剂量。在DSC治疗后立即以及3个月后由同一位皮肤科医生记录特应性皮炎评分（SCORAD）指数。
所有组均观察到良好的临床效果，DSC治疗后立即和3个月后SCORAD的总体改善分别达到87.5±13.4%和71.3±21.3%。治疗期间未观察到副作用。累积暴露时间越长，效果越好，缓解越明显。
死海气候疗法是治疗儿童AD的一个有价值的选择。医学控制和规定的日照似乎对所获得的结果有直接和积极的影响。
