Vollebregt P F, Elfrink A K E, Meijerink W J H J, Felt-Bersma R J F
Department of Gastroenterology and Hepatology, VU Medical Center Amsterdam, De Boelelaan 1118, 1081 HZ, Amsterdam, The Netherlands.
Department of Surgery, VU Medical Center Amsterdam, Amsterdam, The Netherlands.
Tech Coloproctol. 2016 Sep;20(9):633-9. doi: 10.1007/s10151-016-1502-y. Epub 2016 Jul 5.
The aim of the present study was to determine the success rate, quality of life and predictive factors of success associated with long-term rectal cleansing (RC) for defecatory disorders.
All patients who started RC between January 2010 and August 2014 in our referral hospital were sent questionnaires concerning actual RC, Short Form 36 Health Survey (SF-36), Fecal Incontinence Quality of Life (FI-QoL) and the Beck Depression Inventory (BDI). In addition, they were contacted in May and December 2015 for further follow-up information.
Eighty-six patients were offered RC, and 60 patients (45 women, 15 men) started RC. Thirty-three (55 %) patients stopped RC after a median time of 6 months. Twenty-seven (45 %) continued for a median time of 12 months. Forty-three (72 %) patients responded to the questionnaires. SF-36 showed that patients still using RC had more energy and were less fatigued than patients who discontinued therapy. No significant difference was found between patients who stopped and continued RC concerning age, gender, defecation disturbance, underlying disorders, anorectal function, colon-transit time, FI-QoL or BDI-score. Twenty-three patients (38 %) were still performing RC after 21 months, 22 patients (37 %) after 28 months and 1 patient was lost to follow-up.
RC is a moderately effective long-term alternative in patients who do not respond to medical therapy and biofeedback exercises. There is a high dropout rate in the first months, but a moderate rate of continuation in the period hereafter. No predictive factors for continuation were found in medical history or function tests. Those who continued RC performed better on the SF-36 subscale energy/fatigue.
本研究旨在确定长期直肠清洁(RC)治疗排便障碍的成功率、生活质量及成功的预测因素。
2010年1月至2014年8月在我院接受直肠清洁治疗的所有患者均收到关于实际直肠清洁情况、简明健康状况调查量表(SF-36)、大便失禁生活质量量表(FI-QoL)及贝克抑郁量表(BDI)的问卷。此外,在2015年5月和12月与他们联系以获取进一步的随访信息。
86例患者接受直肠清洁治疗,60例患者(45例女性,15例男性)开始直肠清洁治疗。33例(55%)患者在中位时间6个月后停止直肠清洁治疗。27例(45%)患者持续治疗中位时间为12个月。43例(72%)患者回复了问卷。SF-36显示,仍在接受直肠清洁治疗的患者比停止治疗的患者精力更充沛、疲劳感更轻。在停止和继续直肠清洁治疗的患者之间,在年龄、性别、排便障碍、基础疾病、肛肠功能、结肠传输时间、FI-QoL或BDI评分方面未发现显著差异。23例(38%)患者在21个月后仍在进行直肠清洁治疗,22例(37%)在28个月后仍在进行,1例失访。
对于药物治疗和生物反馈训练无效的患者,直肠清洁是一种中度有效的长期替代治疗方法。最初几个月的退出率较高,但在此后的时间段内继续治疗的比例适中。在病史或功能测试中未发现继续治疗的预测因素。继续进行直肠清洁治疗的患者在SF-36能量/疲劳分量表上表现更好。