Keck P E, Vuckovic A, Pope H G, Nierenberg A A, Gribble G W, White K
Epidemiology Laboratory, McLean Hospital, Belmont, Massachusetts 02178.
J Clin Psychopharmacol. 1989 Jun;9(3):203-6.
Despite the widespread use of monoamine oxidase inhibitors (MAOIs) and the well-known adverse event of hypertensive crisis, few studies have addressed the acute cardiovascular response to an MAOI dose. We prospectively measured pulse and blood pressure changes just before and at 1, 2, 3, and 4 hours after MAOI administration in 18 patients. Significant but asymptomatic increases from baseline in mean systolic and diastolic blood pressure occurred within 2 hours after MAOI administration, with return to near baseline by 4 hours. The mechanism of this reaction is unknown.
尽管单胺氧化酶抑制剂（MAOIs）被广泛使用，且高血压危象这一众所周知的不良事件也广为人知，但很少有研究探讨MAOI剂量引起的急性心血管反应。我们前瞻性地测量了18例患者在服用MAOI之前以及之后1、2、3和4小时的脉搏和血压变化。服用MAOI后2小时内，平均收缩压和舒张压较基线有显著但无症状的升高，到4小时时恢复至接近基线水平。这种反应的机制尚不清楚。
