Churesigaew S
J Med Assoc Thai. 1989 Apr;72(4):198-201.
Fifty-nine girls with premature thelarche who attended the endocrine clinic at Children's hospital from 1980 to 1984 were studied. These girls were followed up for at least 3 years. The onset of premature thelarche was found in every age group from birth to below 96 months of age. Approximately 50 per cent of the cases had the onset between the age of 19 months and 96 months. In 44.1 per cent breast enlargement was unilateral. Forty-three patients (72.9%) had persistent breast enlargement for 3 years or more. Sixteen patients (27.1%) had progressive breast enlargement and 45.8 per cent had unchanged breast size at the time of the study. Premature thelarche resolved completely in 16 cases. The duration of regression ranged from 3-60 months, with a mean of 23 months. Premature thelarche is a benign condition but physicians must be cautious when predicting the outcome of breast enlargement. Periodic examination is essential to detect the other pubertal signs and do further investigations as necessary.
对1980年至1984年在儿童医院内分泌门诊就诊的59例性早熟女童进行了研究。这些女童至少随访了3年。性早熟的发病可见于从出生到96个月以下的各个年龄组。约50%的病例发病年龄在19个月至96个月之间。44.1%的病例乳房增大为单侧。43例（72.9%）乳房持续增大3年或更长时间。16例（27.1%）乳房进行性增大，45.8%在研究时乳房大小无变化。16例性早熟完全消退。消退持续时间为3 - 60个月，平均23个月。性早熟是一种良性疾病，但医生在预测乳房增大的结果时必须谨慎。定期检查对于发现其他青春期体征并在必要时进行进一步检查至关重要。
