体内 MRI 和 X 射线双功能成像的聚合物复合材料补充 GdPO4·H2O 纳米束用于追踪骨植入物和骨再生。
In Vivo MRI and X-Ray Bifunctional Imaging of Polymeric Composite Supplemented with GdPO4 ·H2 O Nanobundles for Tracing Bone Implant and Bone Regeneration.
机构信息
College of Chemistry, Jilin University, Changchun, 130012, P. R. China.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
出版信息
Adv Healthc Mater. 2016 Sep;5(17):2182-90. doi: 10.1002/adhm.201600249. Epub 2016 Jul 6.
Homogeneous and monodisperse GdPO4 ·H2 O nanobundles are successfully synthesized via a solvothermal method. Then, GdPO4 ·H2 O are incorporated into the composite of hydroxyapatite and poly(lactic-co-glycolic acid) to obtain a biodegradable and traceable bone implant. After implanted, the GdPO4 ·H2 O/HA/PLGA implant and the newly formed bone can be easily traced and observed through the combination of magnetic resonance imaging and X-ray imaging.
通过溶剂热法成功合成了均匀、单分散的 GdPO4·H2O 纳米束。然后，GdPO4·H2O 被掺入到羟基磷灰石和聚（乳酸-共-乙醇酸）的复合材料中，得到一种可生物降解且可追踪的骨植入物。植入后，通过磁共振成像和 X 射线成像的结合，可以很容易地追踪和观察 GdPO4·H2O/HA/PLGA 植入物和新形成的骨骼。
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