Wasnich R D, Ross P D, Davis J W, Vogel J M
University of Hawaii John A. Burns School of Medicine, Honolulu.
J Nucl Med. 1989 Jul;30(7):1166-71.
In a prospective study of 699 women, 39 new spine fracture cases were observed during a mean follow-up of 3.6 yr. Spine fracture incidence was compared to initial bone mineral content (BMC) of the calcaneus, distal radius, proximal radius, and the lumbar spine. BMC at all four sites was significantly related to spine fracture incidence. Women at -1 s.d. for calcaneal BMC had a sevenfold greater probability of spine fracture than women at +1 s.d.; women at -2 s.d. had a 50-fold greater probability than women at +2 s.d., even after adjustment for the effects of age. Combinations of BMC at two sites further strengthened the relationship to spine fracture; the best two-site combination is calcaneus and distal radius BMC. Thus women can be categorized and stratified according to future fracture risk, and the selection of postmenopausal women for preventive treatments can be guided by measurements of BMC.
在一项针对699名女性的前瞻性研究中，在平均3.6年的随访期内观察到39例新发脊柱骨折病例。将脊柱骨折发病率与跟骨、桡骨远端、桡骨近端和腰椎的初始骨矿物质含量（BMC）进行比较。所有四个部位的BMC均与脊柱骨折发病率显著相关。跟骨BMC处于-1标准差的女性发生脊柱骨折的概率比处于+1标准差的女性高7倍；即使在调整年龄影响后，处于-2标准差的女性发生脊柱骨折的概率比处于+2标准差的女性高50倍。两个部位的BMC组合进一步强化了与脊柱骨折的关系；最佳的两个部位组合是跟骨和桡骨远端BMC。因此，可以根据未来骨折风险对女性进行分类和分层，并且可以通过测量BMC来指导绝经后女性预防性治疗的选择。
