He Xuexiu, Li Chunmei, Wei Zhengkai, Wang Jingjing, Kou Jinhua, Liu Weijian, Shi Mingyu, Yang Zhengtao, Fu Yunhe
College of Veterinary Medicine, Jilin University, Jilin, Changchun 130062, People's Republic of China.
College of Veterinary Medicine, Jilin University, Jilin, Changchun 130062, People's Republic of China.
Eur J Pharmacol. 2016 Oct 15;789:215-221. doi: 10.1016/j.ejphar.2016.07.003. Epub 2016 Jul 5.
This study aimed to investigate the effects and molecular mechanisms of the effects of apigenin on cisplatin (CP)-induced kidney injury in mice. Apigenin was intraperitoneally administered for 3 consecutive days before CP treatment. We found that apigenin pretreatment significantly attenuated the damage to the kidneys and decreased the levels of serum creatinine, blood urea nitrogen (BUN), glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD), which were increased by CP. Apigenin significantly decreased the levels of TNF-α, IL-1β and TGFβ in the kidneys. Additionally, apigenin inhibited the activations of CYP2E1, phospho-NF-κB p65 and phospho-P38 MAPK in CP-induced renal injury. These results suggest that the renoprotective effects of apigenin may be related to the suppressions of oxidative stress and inflammation in CP-induced renal injury in mice.
本研究旨在探讨芹菜素对顺铂（CP）诱导的小鼠肾损伤的影响及其分子机制。在CP处理前连续3天腹腔注射芹菜素。我们发现，芹菜素预处理显著减轻了对肾脏的损伤，并降低了血清肌酐、血尿素氮（BUN）、谷胱甘肽过氧化物酶（GSH-PX）和超氧化物歧化酶（SOD）的水平，这些指标在CP处理后均升高。芹菜素显著降低了肾脏中TNF-α、IL-1β和TGFβ的水平。此外，芹菜素抑制了CP诱导的肾损伤中CYP2E1、磷酸化NF-κB p65和磷酸化P38 MAPK的激活。这些结果表明，芹菜素的肾脏保护作用可能与抑制CP诱导的小鼠肾损伤中的氧化应激和炎症有关。
