Moskow B S
Division of Periodontics, Columbia University, School of Dental and Oral Surgery, New York, NY.
J Periodontol. 1989 May;60(5):271-8. doi: 10.1902/jop.1989.60.5.271.
Dental and periodontal findings associated with primary hyperoxaluria in a 29-year old male patient are described. This is a rare, inherited, metabolic disease which results in excessive calcium oxalate synthesis. The predominant and early manifestation of hyperoxaluria is nephrocalcinosis which results in chronic renal failure. Widespread extrarenal deposits of calcium oxalate crystals, however, is a consistent finding. Extensive infiltration of crystals was noted in the pulps of the teeth, in the marrow spaces of the alveolar bone, in the gingival corium, and in the periodontal ligament. Crystalline calcium oxalate deposits in the periodontal ligament provoked a granulomatous foreign-body reaction. This resulted in aggressive external root resorption leading to pulp exposure and tooth mobility.
描述了一名29岁男性原发性高草酸尿症患者的牙齿和牙周检查结果。这是一种罕见的遗传性代谢疾病，可导致草酸钙过度合成。高草酸尿症的主要早期表现是肾钙质沉着症，可导致慢性肾衰竭。然而，草酸钙晶体在肾外广泛沉积是一个常见发现。在牙髓、牙槽骨骨髓腔、牙龈真皮层和牙周韧带中均发现晶体广泛浸润。牙周韧带中的草酸钙晶体沉积引发了肉芽肿性异物反应。这导致侵袭性牙根外吸收，进而导致牙髓暴露和牙齿松动。
