Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Department of Sociology, San Diego State University, San Diego, CA, USA.
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Psychiatry Res Neuroimaging. 2016 Aug 30;254:92-102. doi: 10.1016/j.pscychresns.2016.06.007. Epub 2016 Jun 18.
Delinquent youth have substantial trauma exposure, with life-course persistent delinquents [LCPD] demonstrating notably elevated cross-diagnostic psychopathology and cognitive deficits. Because adolescents remain in the midst of brain and neurocognitive development, tailored interventions are key to improving functional outcomes. This structural magnetic resonance imaging study compared neuroanatomical profiles of 23 LCPD and 20 matched control adolescent boys. LCPD youth had smaller overall gray matter, and left hippocampal, volumes alongside less cortical surface area and folding within the left pars opercularis and supramarginal cortex. LCPD youth had more adversity-related exposures, and their higher Cumulative Trauma, Adversity and Grief [C-TAG] symptoms were associated with less surface area and folding in the pars opercularis and lingual gyrus. Neuroanatomical differences between LCPD and control youth overlap with data from both maltreatment and antisocial literatures. The affected left frontal regions also share connections to language- and executive-related functions, aligning well with LCPD youths' cognitive and behavioral difficulties. These data also dovetail with research suggesting the possibility of neurodevelopmental delays or disruptions related to cumulative adversity burden. Thus, concurrent treatment of LCPD youths' C-TAG symptoms and, cognitive deficits with overlapping neuroanatomical bases, may be most effective in improving outcomes and optimizing neurodevelopmental trajectories.
问题青年有大量的创伤暴露，具有终生持续性犯罪倾向的问题青年[LCPD]表现出明显更高的跨诊断精神病理学和认知缺陷。由于青少年仍处于大脑和神经认知发展的过程中，量身定制的干预措施对于改善功能结果至关重要。这项结构磁共振成像研究比较了 23 名 LCPD 和 20 名匹配的对照青少年男孩的神经解剖结构特征。LCPD 青年的总灰质、左海马体体积较小，左额下回和缘上回的皮质表面积和折叠较少。LCPD 青年经历了更多与逆境相关的暴露，他们更高的累积创伤、逆境和悲伤[C-TAG]症状与额下回和舌回的表面积和折叠减少有关。LCPD 和对照组青年之间的神经解剖差异与虐待和反社会文献中的数据重叠。受影响的左侧额叶区域还与语言和执行相关功能有关，这与 LCPD 青年的认知和行为困难非常吻合。这些数据也与研究结果相吻合，表明与累积逆境负担相关的神经发育延迟或中断的可能性。因此，同时治疗 LCPD 青年的 C-TAG 症状和具有重叠神经解剖基础的认知缺陷，可能最有效地改善结果并优化神经发育轨迹。
