1 Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
2 Modeling of Noncommunicable Disease Research Center, Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
Stat Methods Med Res. 2018 Apr;27(4):1187-1201. doi: 10.1177/0962280216657376. Epub 2016 Jul 7.
This study proposes semiparametric models for analysis of hierarchical count data containing excess zeros and overdispersion simultaneously. The methods discussed in this paper handle nonlinear covariate effects through flexible semiparametric multilevel regression techniques. This is performed by providing a comprehensive comparison of semiparametric multilevel zero-inflated negative binomial and semiparametric multilevel zero-inflated generalized Poisson models under the real and simulated data. An EM algorithm based on Newton-Raphson equations for maximum penalized likelihood estimation approach is developed. The performance of the proposed models is assessed by using a Monte Carlo simulation study. We also illustrated the methods by the analysis of decayed, missing, and filled teeth of children aged 5-14 years old.
本研究提出了用于分析同时包含过量零值和过离散的层次计数数据的半参数模型。本文讨论的方法通过灵活的半参数多层次回归技术处理非线性协变量效应。这是通过在真实数据和模拟数据下对半参数多层次零膨胀负二项式和半参数多层次零膨胀广义泊松模型进行全面比较来实现的。为了进行最大惩罚似然估计,开发了一种基于牛顿-拉普森方程的 EM 算法。通过蒙特卡罗模拟研究评估了所提出模型的性能。我们还通过分析 5-14 岁儿童的龋齿、缺失和填充牙齿来说明这些方法。