一对从法属西印度群岛马提尼克岛返回的夫妇血浆、尿液和唾液中寨卡病毒的病毒载量动力学

Viral load kinetics of Zika virus in plasma, urine and saliva in a couple returning from Martinique, French West Indies.

作者信息

Fourcade Camille, Mansuy Jean-Michel, Dutertre Marine, Delpech Marie, Marchou Bruno, Delobel Pierre, Izopet Jacques, Martin-Blondel Guillaume

机构信息

Toulouse University Hospital, Toulouse, France.

Saint-Gaudens Hospital, Saint-Gaudens, France.

出版信息

J Clin Virol. 2016 Sep;82:1-4. doi: 10.1016/j.jcv.2016.06.011. Epub 2016 Jun 22.

DOI:10.1016/j.jcv.2016.06.011

PMID:27389909

Abstract

While the rapid spread of Zika virus (ZIKV) in South America has been declared a public health emergency few data are available on the kinetics of the virus load and the specific antibodies in individual patients. This report describes the kinetics of ZIKV decay in the body compartments and the kinetics of anti ZIKV IgG and IgM of two people returning from Martinique, French West Indies. ZIKV remained detectable in the plasma for roughly 2 weeks indicating that mosquito control measures should be prolonged accordingly. Remarkably, their urine samples consistently tested positive for even longer. The antibodies responses were different between the two patients but for both the rapid onset of IgM allowed a diagnosis from the end of the first week.

摘要

虽然寨卡病毒（ZIKV）在南美洲的迅速传播已被宣布为突发公共卫生事件，但关于个体患者体内病毒载量动力学和特异性抗体的可用数据却很少。本报告描述了从法属西印度群岛马提尼克岛返回的两名患者体内ZIKV在身体各部位的衰减动力学以及抗ZIKV IgG和IgM的动力学。ZIKV在血浆中大约可检测到2周，这表明蚊虫控制措施应相应延长。值得注意的是，他们的尿液样本检测呈阳性的时间甚至更长。两名患者的抗体反应有所不同，但对于两人来说，IgM的快速出现使得从第一周结束时就可以做出诊断。