“三分之二”：一种密码子阅读的替代方法。
"Two out of three": an alternative method for codon reading.
作者信息
Lagerkvist U
出版信息
Proc Natl Acad Sci U S A. 1978 Apr;75(4):1759-62. doi: 10.1073/pnas.75.4.1759.
Abstract
An alternative method for codon reading, whereby only the first two codon nucleotides are recognized by the anticodon, is discussed and the experimental evidence for this "two of three" reading method is reviewed. Misreading of codons by the "two out of three" method could pose a significant threat to the fidelity of protein synthesis unless the genetic code is organized in such a way as to prevent this method from being used when it might compromise translational fidelity. Inspection of the genetic code shows that it is arranged in such a way that the "two out of three" reading method can be used without translational errors.
摘要
本文讨论了一种密码子读取的替代方法，即反密码子仅识别前两个密码子核苷酸，并综述了这种“三个中的两个”读取方法的实验证据。除非遗传密码以某种方式组织起来，以防止这种方法在可能损害翻译保真度时被使用，否则通过“三个中的两个”方法误读密码子可能对蛋白质合成的保真度构成重大威胁。对遗传密码的检查表明，它的排列方式使得“三个中的两个”读取方法可以在不产生翻译错误的情况下使用。
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