Collet M, Urbanek R
Universitäts-Kinderklinik Freiburg i. Br.
Klin Padiatr. 1989 May-Jun;201(3):183-8. doi: 10.1055/s-2007-1025299.
A perennial hyposensitization treatment over 2 years was performed in 18 pollen-allergic patients (14 children, 4 adults) with a standardized and purified graspollen extract. The selection for therapy was provided by allergen titration in skin prick test, conjunctival test and by the estimation of specific IgE to timothy. The reported decrease of seasonal symptoms was accompanied by reduced sensitivity in skin test and conjunctival provocation test (p less than 0.001, p less than 0.05). No consistent change in specific IgE was observed at the end of the study. Specific IgG antibodies significantly rised and persisted (p less than 0.001). A successful hyposensitization treatment with graspollen could be monitored by in-vivo and in-vitro parameters.
对18名花粉过敏患者（14名儿童，4名成人）使用标准化纯化的禾本科花粉提取物进行了为期2年的常年性减敏治疗。通过皮肤点刺试验、结膜试验中的变应原滴定以及对梯牧草特异性IgE的评估来选择治疗对象。报告显示季节性症状减轻的同时，皮肤试验和结膜激发试验的敏感性降低（p<0.001，p<0.05）。研究结束时未观察到特异性IgE有一致变化。特异性IgG抗体显著升高并持续存在（p<0.001）。禾本科花粉的成功减敏治疗可通过体内和体外参数进行监测。
