白内障增加外周动脉闭塞性疾病风险：一项基于全国人群的倾向评分队列研究。
Cataract increases the risk of peripheral artery occlusive disease: A nationwide population-based cohort study with propensity score.
作者信息
Hu Wei-Syun, Lin Cheng-Li, Huang Chih-Yang, Chang Shih-Sheng, Chang Kuan-Cheng
机构信息
School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan; Division of Cardiovascular Medicine, Department of Medicine, China Medical University Hospital, Taichung 40447, Taiwan.
Management Office for Health Data, China Medical University Hospital, Taichung 40447, Taiwan.
出版信息
Int J Cardiol. 2016 Oct 1;220:768-71. doi: 10.1016/j.ijcard.2016.06.084. Epub 2016 Jun 23.
PURPOSE
We conducted this study to evaluate the risk of peripheral artery occlusive disease (PAOD) among patients with cataracts.
METHODS
We analyzed the data from Taiwan National Health Insurance Research Database. Study participants were classified into the cataract group and the non-cataract group between 2000 and 2010. All patients were observed from the index year until PAOD diagnosis, loss to follow up, or the end of 2011. Both study groups were 1:1 matching based upon a propensity score. We used a cox proportional hazards regression model to assess the hazard ratio (HR) and 95% confidence interval (CI) of PAOD for the cataract cohort compared with the non-cataract cohort.
RESULTS
After adjustment for age, sex and comorbidities, the risk of PAOD was significantly higher in the cataract cohort [adjusted HR (aHR)=1.48, 95% CI=1.38-1.58] than the non-cataract cohort.
CONCLUSIONS
We found that patients with cataracts had a 1.48-fold increased risk of developing PAOD compared to the non-cataract patients.
目的
我们开展本研究以评估白内障患者外周动脉闭塞性疾病（PAOD）的风险。
方法
我们分析了台湾国民健康保险研究数据库中的数据。研究参与者在2000年至2010年间被分为白内障组和非白内障组。所有患者从索引年份开始观察，直至PAOD诊断、失访或2011年底。两个研究组根据倾向得分进行1:1匹配。我们使用Cox比例风险回归模型评估白内障队列与非白内障队列相比PAOD的风险比（HR）和95%置信区间（CI）。
结果
在调整年龄、性别和合并症后，白内障队列中PAOD的风险显著高于非白内障队列[调整后HR（aHR）=1.48，95%CI=1.38 - 1.58]。
结论
我们发现，与非白内障患者相比，白内障患者发生PAOD的风险增加了1.48倍。
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