通过蛋白质工程绘制蛋白质折叠的过渡态和途径
Mapping the transition state and pathway of protein folding by protein engineering.
作者信息
Matouschek A, Kellis J T, Serrano L, Fersht A R
机构信息
MRC Unit for Protein Function and Design, University of Cambridge, UK.
出版信息
Nature. 1989 Jul 13;340(6229):122-6. doi: 10.1038/340122a0.
DOI:10.1038/340122a0
PMID:2739734
Abstract
In the transition state for unfolding of barnase, the hydrophobic core between the major alpha-helix and beta-sheet is somewhat weakened, the C terminus of the major helix is largely intact but its N terminus is exposed and a major loop has been invaded by solvent.
摘要
在巴恩核酸酶展开的过渡态中，主要α-螺旋和β-折叠之间的疏水核心有所减弱，主要螺旋的C末端基本完整但其N末端暴露，并且一个主要环已被溶剂侵入。
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