Durnwald Celeste P, Kallan Michael J, Allison Kelly C, Sammel Mary D, Wisch Susan, Elovitz Michal, Parry Samuel
Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Am J Perinatol. 2016 Oct;33(12):1145-51. doi: 10.1055/s-0036-1585085. Epub 2016 Jul 11.
Objective To evaluate whether women with gestational diabetes mellitus (GDM) enrolled in an intensive behavior education program (IBEP) demonstrate lower mean fasting glucose levels on the 2-hour 75 g oral glucose tolerance test (2-hour OGTT) at 6 to 12 weeks postpartum compared with women who undergo routine GDM management. Study Design A prospective randomized controlled trial of women diagnosed with GDM was conducted. Exclusion criteria were GDM diagnosis ≥ 33 weeks or < 20 weeks. Women were randomly assigned to one of two treatment arms: (1) routine GDM management or (2) an IBEP. Women underwent a 2-hour OGTT at 6 to 12 weeks postpartum. Fisher exact test, t-test, and Wilcoxon rank sum test were used as appropriate. Results Of the 101 women randomized, 49 were assigned to IBEP and 52 received routine GDM management. There was no difference in mean fasting and 2-hour glucose levels on the postpartum 2-hour OGTT between the IBEP and routine management group (88.5 ± 22.9 mg/dL vs. 85.2 ± 13.3 mg/dL, p = 0.49 and 109.8 ± 38.5 mg/dL vs. 109.4 ± 40.8 mg/dL, p = 0.97, respectively). Conclusion GDM women enrolled in a healthy lifestyle intervention program did not demonstrate lower glucose values on the postpartum 2-hour OGTT.
评估参加强化行为教育项目（IBEP）的妊娠期糖尿病（GDM）女性在产后6至12周进行的2小时75克口服葡萄糖耐量试验（2小时OGTT）中，其空腹血糖平均水平是否低于接受常规GDM管理的女性。研究设计：对诊断为GDM的女性进行一项前瞻性随机对照试验。排除标准为GDM诊断孕周≥33周或<20周。女性被随机分配到两个治疗组之一：（1）常规GDM管理组或（2）IBEP组。女性在产后6至12周进行2小时OGTT。根据情况使用Fisher精确检验、t检验和Wilcoxon秩和检验。结果：在101名随机分组的女性中，49名被分配到IBEP组，52名接受常规GDM管理。IBEP组和常规管理组在产后2小时OGTT的空腹血糖和2小时血糖平均水平上没有差异（分别为88.5±22.9毫克/分升对85.2±13.3毫克/分升，p = 0.49；109.8±38.5毫克/分升对109.4±40.8毫克/分升，p = 0.97）。结论：参加健康生活方式干预项目的GDM女性在产后2小时OGTT中并未表现出更低的血糖值。
