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前沿领域的染色质与表观遗传学:在峰中寻找线索

Chromatin and Epigenetics at the Forefront: Finding Clues among Peaks.

作者信息

Aranda Sergi, Shi Yang, Di Croce Luciano

机构信息

Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain Universitat Pompeu Fabra (UPF), Barcelona, Spain

Department of Cell Biology, Harvard Medical School, and Division of Newborn Medicine, Children's Hospital Boston, Boston, Massachusetts, USA.

出版信息

Mol Cell Biol. 2016 Sep 12;36(19):2432-9. doi: 10.1128/MCB.00328-16. Print 2016 Oct 1.

Abstract

The Keystone Symposium on Chromatin and Epigenetics, organized by Luciano Di Croce (Center for Genomic Regulation, Spain) and Yang Shi (Harvard Medical School, USA), took place 20 to 24 March 2016 at Whistler (British Columbia, Canada). The symposium brought together some of the most outstanding scientists studying how chromatin structure and epigenetic mechanisms regulate gene function in both development and disease. Junior scientists had the opportunity to interact with experienced researchers by presenting their work and discussing ideas and novel hypotheses. In order to foster interaction and networking, the scientific agenda was balanced with an extended social agenda. This meeting review describes several of the most provocative and exciting talks from the symposium, revealing how fast this research field is evolving and the profound impact it will have on human health.

摘要

由卢西亚诺·迪·克罗切(西班牙基因组调控中心)和施杨(美国哈佛医学院)组织的染色质与表观遗传学凯斯通研讨会于2016年3月20日至24日在加拿大不列颠哥伦比亚省惠斯勒举行。该研讨会汇聚了一些研究染色质结构和表观遗传机制如何在发育和疾病中调节基因功能的最杰出科学家。初级科学家有机会通过展示他们的工作并讨论想法和新假设,与经验丰富的研究人员进行互动。为了促进互动和交流,科学议程与扩展的社交议程达到了平衡。本次会议综述介绍了研讨会上几个最具启发性和令人兴奋的演讲,揭示了这个研究领域的发展速度之快以及它将对人类健康产生的深远影响。

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本文引用的文献

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Activation of proto-oncogenes by disruption of chromosome neighborhoods.染色体邻域破坏导致原癌基因激活。
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