Robati Reza M, Einollahi Bahram, Einollahi Hoda, Younespour Shima, Fadaifard Shahed
Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Ophthalmology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Scientifica (Cairo). 2016;2016:6789081. doi: 10.1155/2016/6789081. Epub 2016 Jun 15.
Background. Keratoconus is a relatively common corneal disease causing significant visual disability. Individuals with connective tissue disorders that affect the skin such as Marfan's syndrome and Ehlers-Danlos syndrome or patients with atopic dermatitis show an increased prevalence of keratoconus. It seems that there are some concurrent alterations of skin and cornea in patients with keratoconus. Objective. We plan to compare skin biophysical characteristics in patients with keratoconus and healthy controls. Methods. Forty patients with keratoconus (18 females and 22 males) with mean (SD) age of 33.32 (9.55) years (range 19-56) and 40 healthy controls were recruited to this study. Skin biophysical characteristics including cutaneous resonance running time (CRRT), stratum corneum hydration, and melanin values were measured in patients and controls. Results. The median CRRT, stratum corneum hydration, and melanin measurements were significantly lower in patients with keratoconus in comparison with healthy controls. Conclusion. There are some alterations of skin biophysical properties in patients with keratoconus. Therefore, the assessment of these skin parameters could provide us some clues to the possible common biophysical variations of cornea and skin tissue in diseases such as keratoconus.
背景。圆锥角膜是一种相对常见的角膜疾病，可导致严重的视力残疾。患有影响皮肤的结缔组织疾病（如马凡综合征和埃勒斯-丹洛斯综合征）的个体或特应性皮炎患者中圆锥角膜的患病率增加。圆锥角膜患者似乎存在皮肤和角膜的一些并发改变。目的。我们计划比较圆锥角膜患者和健康对照者的皮肤生物物理特征。方法。本研究招募了40例圆锥角膜患者（18例女性和22例男性），平均（标准差）年龄为33.32（9.55）岁（范围19 - 56岁）以及40名健康对照者。对患者和对照者测量皮肤生物物理特征，包括皮肤共振运行时间（CRRT）、角质层水合作用和黑色素值。结果。与健康对照者相比，圆锥角膜患者的CRRT中位数、角质层水合作用和黑色素测量值显著更低。结论。圆锥角膜患者存在皮肤生物物理特性的一些改变。因此，对这些皮肤参数的评估可为我们提供一些线索，以了解圆锥角膜等疾病中角膜和皮肤组织可能存在的共同生物物理变化。
