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SABRE: a multicentre randomised control trial of nebulised hypertonic saline in infants hospitalised with acute bronchiolitis.SABRE：一项针对因急性细支气管炎住院的婴儿雾化吸入高渗盐水的多中心随机对照试验。
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Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis.临床实践指南：细支气管炎的诊断、管理及预防
Pediatrics. 2014 Nov;134(5):e1474-502. doi: 10.1542/peds.2014-2742.
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The effect of 3% and 6% hypertonic saline in viral bronchiolitis: a randomised controlled trial.3%和 6%高渗盐水治疗病毒性细支气管炎的效果：一项随机对照试验。
Eur Respir J. 2014 Oct;44(4):913-21. doi: 10.1183/09031936.00159613. Epub 2014 Jun 25.
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Bronchodilators for bronchiolitis.用于治疗细支气管炎的支气管扩张剂。
Cochrane Database Syst Rev. 2014 Jun 17;2014(6):CD001266. doi: 10.1002/14651858.CD001266.pub4.
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The efficacy of nebulized salbutamol, magnesium sulfate, and salbutamol/magnesium sulfate combination in moderate bronchiolitis.雾化吸入沙丁胺醇、硫酸镁及沙丁胺醇/硫酸镁联合用药治疗中度细支气管炎的疗效
Eur J Pediatr. 2014 Sep;173(9):1157-60. doi: 10.1007/s00431-014-2309-3. Epub 2014 Apr 2.
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7% Hypertonic saline in acute bronchiolitis: a randomized controlled trial.急性细支气管炎中 7%高渗盐水：一项随机对照试验。
Pediatrics. 2014 Jan;133(1):e8-13. doi: 10.1542/peds.2013-1646. Epub 2013 Dec 16.
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Nebulised hypertonic saline solution for acute bronchiolitis in infants.雾化高渗盐水溶液用于婴儿急性细支气管炎
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Glucocorticoids for acute viral bronchiolitis in infants and young children.糖皮质激素用于婴幼儿急性病毒性细支气管炎
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10
Emergency room management of acute bronchiolitis: a randomized trial of nebulized epinephrine.急性细支气管炎的急诊室管理：雾化肾上腺素的一项随机试验
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比较7%、3%和0.9%生理盐水治疗婴儿中重度细支气管炎的疗效。

Comparing the Efficacy of 7%, 3% and 0.9% Saline in Moderate to Severe Bronchiolitis in Infants.

作者信息

Köse Seçil, Şehriyaroğlu Ahmet, Esen Feyza, Özdemir Ahmet, Kardaş Zehra, Altuğ Umut, Karakuş Esef, Özcan Alper, Kısaarslan Ali Fatih, Elmalı Ferhan, Torun Yasemin Altuner, Köse Mehmet

机构信息

Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey.

Departments of Biostatistics and Bioinformatics, Erciyes University School of Medicine, Kayseri, Turkey.

出版信息

Balkan Med J. 2016 Mar;33(2):193-7. doi: 10.5152/balkanmedj.2016.16840. Epub 2016 Mar 1.

DOI:10.5152/balkanmedj.2016.16840
PMID:27403389
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4924964/
Abstract

BACKGROUND

There is no standard treatment option in acute bronchiolitis. 3-7% hypertonic saline (HS) seems to be the effective treatment choice for reducing the hospitalization day.

AIMS

To compare the effect of nebulized 7% HS/salbutamol and 3% HS/salbutamol to 0.9% saline/salbutamol. The primary outcome measure was the effect of study drugs on the length of hospital stay (LOS). Secondary outcome measures were safety and efficacy in reducing the clinical severity score (CSS) at the 24 hours of the study.

STUDY DESIGN

Prospective, double-blinded randomized clinical study.

METHODS

The study consists of 104 infants. Groups were constituted according to the treatment they received: These are, group A - 0.9% saline/salbutamol, group B -3% HS/salbutamol and group C-7% HS/salbutamol. Heart beat, Bronchiolitis CSS and oxygen saturation of the patients were determined before and after nebulization. The patients were monitored for adverse reactions.

RESULTS

Length of hospital stay in group A, B and C were as follows; 72.0 (20-288) hours in group A, 64.0 (12-168) hours in group B and 60.0 (12-264) hours in group C. No significant differences was observed among three groups (p>0.05).

CONCLUSION

7% HS and 3% HS does not have any effect to decrease LOS for infants with bronchiolitis.

摘要

背景

急性细支气管炎尚无标准治疗方案。3%-7%的高渗盐水（HS）似乎是缩短住院天数的有效治疗选择。

目的

比较雾化吸入7%HS/沙丁胺醇、3%HS/沙丁胺醇与0.9%生理盐水/沙丁胺醇的效果。主要观察指标是研究药物对住院时间（LOS）的影响。次要观察指标是研究24小时时降低临床严重程度评分（CSS）的安全性和有效性。

研究设计

前瞻性、双盲随机临床研究。

方法

该研究纳入104例婴儿。根据所接受的治疗分组：A组——0.9%生理盐水/沙丁胺醇，B组——3%HS/沙丁胺醇，C组——7%HS/沙丁胺醇。在雾化前后测定患者的心率、细支气管炎CSS和血氧饱和度。对患者进行不良反应监测。

结果

A、B、C组的住院时间如下：A组72.0（20-288）小时，B组64.0（12-168）小时，C组60.0（12-264）小时。三组之间未观察到显著差异（p>0.05）。

结论

7%HS和3%HS对降低细支气管炎婴儿的住院时间无任何作用。