比较7%、3%和0.9%生理盐水治疗婴儿中重度细支气管炎的疗效。
Comparing the Efficacy of 7%, 3% and 0.9% Saline in Moderate to Severe Bronchiolitis in Infants.
作者信息
Köse Seçil, Şehriyaroğlu Ahmet, Esen Feyza, Özdemir Ahmet, Kardaş Zehra, Altuğ Umut, Karakuş Esef, Özcan Alper, Kısaarslan Ali Fatih, Elmalı Ferhan, Torun Yasemin Altuner, Köse Mehmet
机构信息
Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey.
Departments of Biostatistics and Bioinformatics, Erciyes University School of Medicine, Kayseri, Turkey.
出版信息
Balkan Med J. 2016 Mar;33(2):193-7. doi: 10.5152/balkanmedj.2016.16840. Epub 2016 Mar 1.
BACKGROUND
There is no standard treatment option in acute bronchiolitis. 3-7% hypertonic saline (HS) seems to be the effective treatment choice for reducing the hospitalization day.
AIMS
To compare the effect of nebulized 7% HS/salbutamol and 3% HS/salbutamol to 0.9% saline/salbutamol. The primary outcome measure was the effect of study drugs on the length of hospital stay (LOS). Secondary outcome measures were safety and efficacy in reducing the clinical severity score (CSS) at the 24 hours of the study.
STUDY DESIGN
Prospective, double-blinded randomized clinical study.
METHODS
The study consists of 104 infants. Groups were constituted according to the treatment they received: These are, group A - 0.9% saline/salbutamol, group B -3% HS/salbutamol and group C-7% HS/salbutamol. Heart beat, Bronchiolitis CSS and oxygen saturation of the patients were determined before and after nebulization. The patients were monitored for adverse reactions.
RESULTS
Length of hospital stay in group A, B and C were as follows; 72.0 (20-288) hours in group A, 64.0 (12-168) hours in group B and 60.0 (12-264) hours in group C. No significant differences was observed among three groups (p>0.05).
CONCLUSION
7% HS and 3% HS does not have any effect to decrease LOS for infants with bronchiolitis.
背景
急性细支气管炎尚无标准治疗方案。3%-7%的高渗盐水（HS）似乎是缩短住院天数的有效治疗选择。
目的
比较雾化吸入7%HS/沙丁胺醇、3%HS/沙丁胺醇与0.9%生理盐水/沙丁胺醇的效果。主要观察指标是研究药物对住院时间（LOS）的影响。次要观察指标是研究24小时时降低临床严重程度评分（CSS）的安全性和有效性。
研究设计
前瞻性、双盲随机临床研究。
方法
该研究纳入104例婴儿。根据所接受的治疗分组：A组——0.9%生理盐水/沙丁胺醇，B组——3%HS/沙丁胺醇，C组——7%HS/沙丁胺醇。在雾化前后测定患者的心率、细支气管炎CSS和血氧饱和度。对患者进行不良反应监测。
结果
A、B、C组的住院时间如下：A组72.0（20-288）小时，B组64.0（12-168）小时，C组60.0（12-264）小时。三组之间未观察到显著差异（p>0.05）。
结论
7%HS和3%HS对降低细支气管炎婴儿的住院时间无任何作用。
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