Miller Andrew D
Institute of Pharmaceutical Science, Kings College London, Franklin-Wilkins Building, Waterloo Campus, 150 Stamford Street, London SE1 9NH, UK.
KP Therapeutics Ltd, 86 Deansgate, Manchester, M3 2ER, UK.
Ther Deliv. 2016 Jul;7(7):431-56. doi: 10.4155/tde-2016-0020.
Understanding and exploiting molecular mechanisms in biology is central to chemical biology. In 20 years, chemical biology research has advanced from simple mechanistic studies using isolated biological macromolecules to molecular-level and nanomolecular-level mechanistic studies involving whole organisms. This review documents the best of my personal and collaborative academic research work that has made use of a solid organic chemistry and chemical biology approach toward nanomedicine, in which my focus has been on the design, creation and use of synthetic, self-assembly lipid-based nanoparticle technologies for the functional delivery of active pharmaceutical ingredients to target cells in vivo. This research is now leading to precision therapeutics approaches (PTAs) for the treatment of diseases that may define the future of nanomedicine.
理解和利用生物学中的分子机制是化学生物学的核心。在过去的20年里，化学生物学研究已从使用分离的生物大分子进行简单的机制研究，发展到涉及整个生物体的分子水平和纳米分子水平的机制研究。这篇综述记录了我个人以及合作开展的最佳学术研究工作，这些工作采用了扎实的有机化学和化学生物学方法来研究纳米医学，我的重点一直是设计、创建和使用基于脂质的合成自组装纳米颗粒技术，以便在体内将活性药物成分功能性地递送至靶细胞。这项研究正引领着针对疾病治疗的精准治疗方法（PTAs），而这些方法可能会定义纳米医学的未来。
