Carden Marcus A, Caltharp Shelley, Yee Marianne E, Haight Ann E, Westblade Lars F, Park Sunita
*Aflac Cancer and Blood Disorders Center ‡Department of Pathology, Children's Healthcare of Atlanta †Department of Pediatrics, Emory University School of Medicine, Atlanta, GA §Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY.
J Pediatr Hematol Oncol. 2016 Nov;38(8):e310-e314. doi: 10.1097/MPH.0000000000000613.
Monomorphic plasmacytoma-type posttransplant lymphoproliferative disorder (PTLD) has not been reported after pediatric hematopoietic stem cell transplantation. We present a child with hepatitis-associated severe aplastic anemia who underwent an unrelated allogeneic hematopoietic stem cell transplantation and subsequently developed graft failure and an Epstein-Barr virus-positive monomorphic plasmacytoma-type PTLD of recipient origin. Despite broad-spectrum antimicrobials, weaning immunosuppression, rituximab administration, and a stem cell boost she died from complications of PTLD and a fungal pulmonary infection on day +78.
