Egli F, Niemöller U M, Rhyner K
Schweiz Rundsch Med Prax. 1989 May 9;78(19):551-6.
The development of highly specific antibodies against recombinant human erythropoietin (EPO) has recently made the accurate radioimmunological measurement of serum levels of this hormone possible. In this study we determined the serum-EPO levels in 100 healthy volunteers, in 54 patients suffering from polycythemia vera and in 51 patients with secondary polyglobulia. The mean levels for the healthy group were found to be 11.3 +/- 3.4 mU/ml in females and 8.0 +/- 3.2 mU/ml in males. Patients with polycythemia vera had serum-EPO levels of 4.3 mU/ml, while those with secondary polyglobulia had significantly higher levels averaging 30.3 mU/ml (p less than 0.0001). However, an overlapping of serum-EPO values in the range between 10 and 20 mU/ml occasionally occurs. Our results show that measurement of the serum-EPO level can be useful in the differential diagnosis of polyglobulias. Additionally, sequential EPO level measurements after phlebotomy and after hemorrhage show a pronounced increase in serum-EPO in secondary polyglobulia, while in polycythemia vera the level only increases slightly.
针对重组人促红细胞生成素（EPO）的高特异性抗体的研发，最近使得准确放射免疫测定该激素的血清水平成为可能。在本研究中，我们测定了100名健康志愿者、54名真性红细胞增多症患者和51名继发性红细胞增多症患者的血清EPO水平。健康组女性的平均水平为11.3±3.4 mU/ml，男性为8.0±3.2 mU/ml。真性红细胞增多症患者的血清EPO水平为4.3 mU/ml，而继发性红细胞增多症患者的水平显著更高，平均为30.3 mU/ml（p<0.0001）。然而，血清EPO值在10至20 mU/ml之间偶尔会出现重叠。我们的结果表明，血清EPO水平的测定在红细胞增多症的鉴别诊断中可能有用。此外，放血和出血后连续测定EPO水平显示，继发性红细胞增多症患者血清EPO明显升高，而真性红细胞增多症患者的水平仅略有升高。
