一种预测抗结核活性的模型：海洋微生物的价值主张。
A model to predict anti-tuberculosis activity: value proposition for marine microorganisms.
作者信息
Liu Miaomiao, Grkovic Tanja, Zhang Lixin, Liu Xueting, Quinn Ronald J
机构信息
Eskitis Institute for Drug Discovery, Griffith University, Brisbane, QLD, Australia.
Chinese Academy of Sciences, Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
出版信息
J Antibiot (Tokyo). 2016 Aug;69(8):594-9. doi: 10.1038/ja.2016.87. Epub 2016 Jul 13.
The development of new antibiotics effective against all strains of tuberculosis (TB) is needed. To evaluate the potential of marine microbe-derived natural products as anti-TB leads, we analyzed and compared the physico-chemical properties of 39 current TB drugs and candidates against 60 confirmed mycobacteria-active natural products. We showed that anti-TB natural products sourced from marine microbes have a large overlap with TB drug-like space. A model to predict potential anti-TB drugs is proposed.
需要开发对所有结核菌株均有效的新型抗生素。为了评估海洋微生物来源的天然产物作为抗结核先导物的潜力，我们分析并比较了39种当前的抗结核药物及候选药物与60种已证实具有抗分枝杆菌活性的天然产物的物理化学性质。我们发现，源自海洋微生物的抗结核天然产物与类抗结核药物空间有很大重叠。本文提出了一种预测潜在抗结核药物的模型。
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