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一种预测抗结核活性的模型：海洋微生物的价值主张。

A model to predict anti-tuberculosis activity: value proposition for marine microorganisms.

作者信息

Liu Miaomiao, Grkovic Tanja, Zhang Lixin, Liu Xueting, Quinn Ronald J

机构信息

Eskitis Institute for Drug Discovery, Griffith University, Brisbane, QLD, Australia.

Chinese Academy of Sciences, Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

出版信息

J Antibiot (Tokyo). 2016 Aug;69(8):594-9. doi: 10.1038/ja.2016.87. Epub 2016 Jul 13.

DOI:10.1038/ja.2016.87
PMID:27406906
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5399163/
Abstract

The development of new antibiotics effective against all strains of tuberculosis (TB) is needed. To evaluate the potential of marine microbe-derived natural products as anti-TB leads, we analyzed and compared the physico-chemical properties of 39 current TB drugs and candidates against 60 confirmed mycobacteria-active natural products. We showed that anti-TB natural products sourced from marine microbes have a large overlap with TB drug-like space. A model to predict potential anti-TB drugs is proposed.

摘要

需要开发对所有结核菌株均有效的新型抗生素。为了评估海洋微生物来源的天然产物作为抗结核先导物的潜力，我们分析并比较了39种当前的抗结核药物及候选药物与60种已证实具有抗分枝杆菌活性的天然产物的物理化学性质。我们发现，源自海洋微生物的抗结核天然产物与类抗结核药物空间有很大重叠。本文提出了一种预测潜在抗结核药物的模型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590e/5399163/6f4712cfa9e4/ja201687f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590e/5399163/d5bbcd9f9abe/ja201687f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590e/5399163/8dbb3a2200a5/ja201687f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590e/5399163/f0cf676d3bfe/ja201687f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590e/5399163/951e159ec8fa/ja201687f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590e/5399163/b651c01b89f6/ja201687f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590e/5399163/6933571c967a/ja201687f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590e/5399163/63fe20adfccc/ja201687f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590e/5399163/0f403332233d/ja201687f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590e/5399163/6f4712cfa9e4/ja201687f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590e/5399163/d5bbcd9f9abe/ja201687f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590e/5399163/8dbb3a2200a5/ja201687f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590e/5399163/f0cf676d3bfe/ja201687f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590e/5399163/951e159ec8fa/ja201687f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590e/5399163/b651c01b89f6/ja201687f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590e/5399163/6933571c967a/ja201687f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590e/5399163/63fe20adfccc/ja201687f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590e/5399163/0f403332233d/ja201687f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590e/5399163/6f4712cfa9e4/ja201687f9.jpg

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Recent advances in deep-sea natural products.深海天然产物的最新进展。
Nat Prod Rep. 2014 Aug;31(8):999-1025. doi: 10.1039/c3np70118b.
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Association between HIV/AIDS and multi-drug resistance tuberculosis: a systematic review and meta-analysis.艾滋病毒/艾滋病与耐多药结核病之间的关联：一项系统评价和荟萃分析。
Identification of Anti- and Anti- Compounds With Potential Distinctive Structural Scaffolds From an HD-PBL Using Phenotypic Screens in Amoebae Host Models.
利用变形虫宿主模型中的表型筛选，从高密度外周血淋巴细胞中鉴定具有潜在独特结构骨架的抗化合物和抗化合物。
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Natural products: a continuing source of novel drug leads.天然产物：新型药物先导物的持续来源。
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