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TLR7 agonist-induced bronchodilation: key mechanistic questions remain.

作者信息

Drake Matthew G

机构信息

Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon

出版信息

Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L177. doi: 10.1152/ajplung.00172.2016.

Abstract
摘要

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本文引用的文献

1
The TLR7 agonist imiquimod induces bronchodilation via a nonneuronal TLR7-independent mechanism: a possible role for quinoline in airway dilation.
Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1121-9. doi: 10.1152/ajplung.00288.2015. Epub 2016 Apr 15.
2
Toll-like receptor 7 rapidly relaxes human airways.
Am J Respir Crit Care Med. 2013 Sep 15;188(6):664-72. doi: 10.1164/rccm.201303-0442OC.
4
Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs.
J Allergy Clin Immunol. 2011 Feb;127(2):462-9. doi: 10.1016/j.jaci.2010.10.029. Epub 2010 Dec 17.
5
Toll-like receptor 7 mediates pruritus.
Nat Neurosci. 2010 Dec;13(12):1460-2. doi: 10.1038/nn.2683. Epub 2010 Oct 31.
6
Voltage-gated sodium channels in nociceptive versus non-nociceptive nodose vagal sensory neurons innervating guinea pig lungs.
J Physiol. 2008 Mar 1;586(5):1321-36. doi: 10.1113/jphysiol.2007.146365. Epub 2008 Jan 10.

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