Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Nat Neurosci. 2010 Dec;13(12):1460-2. doi: 10.1038/nn.2683. Epub 2010 Oct 31.
Toll-like receptors are typically expressed in immune cells to regulate innate immunity. We found that functional Toll-like receptor 7 (TLR7) was expressed in C-fiber primary sensory neurons and was important for inducing itch (pruritus), but was not necessary for eliciting mechanical, thermal, inflammatory and neuropathic pain in mice. Our results indicate that TLR7 mediates itching and is a potential therapeutic target for anti-itch treatment in skin disease conditions.
Toll 样受体通常在免疫细胞中表达，以调节先天免疫。我们发现功能性 Toll 样受体 7（TLR7）在 C 纤维初级感觉神经元中表达，对于诱导瘙痒（瘙痒）很重要，但对于在小鼠中引起机械、热、炎症和神经性疼痛则不是必需的。我们的结果表明，TLR7 介导瘙痒，是皮肤病治疗止痒的潜在治疗靶点。
