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Toll-like receptor 7 mediates pruritus.
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Allergen-induced histaminergic and non-histaminergic activation of itch C-fiber nerve terminals in mouse skin.
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6
TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice.
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Mouse model of imiquimod-induced psoriatic itch.
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TLR7 negatively regulates dendrite outgrowth through the Myd88-c-Fos-IL-6 pathway.
J Neurosci. 2013 Jul 10;33(28):11479-93. doi: 10.1523/JNEUROSCI.5566-12.2013.

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Toll-like receptors in atopic dermatitis: pathogenesis and therapeutic implications.
Heliyon. 2025 Jan 31;11(3):e42226. doi: 10.1016/j.heliyon.2025.e42226. eCollection 2025 Feb 15.
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Interplay between cannabinoids and the neuroimmune system in migraine.
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Sensory sentinels: Neuroimmune detection and food allergy.
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Immune Stimulation with Imiquimod to Best Face SARS-CoV-2 Infection and Prevent Long COVID.
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Neuroimmune interplay in kidney health and disease: Role of renal nerves.
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IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial.
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Role of pattern recognition receptors in chemotherapy-induced neuropathic pain.
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本文引用的文献

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Pattern recognition receptors and inflammation.
Cell. 2010 Mar 19;140(6):805-20. doi: 10.1016/j.cell.2010.01.022.
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Non-melanoma skin cancer.
Lancet. 2010 Feb 20;375(9715):673-85. doi: 10.1016/S0140-6736(09)61196-X.
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Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus.
Cell. 2009 Dec 24;139(7):1353-65. doi: 10.1016/j.cell.2009.11.034. Epub 2009 Dec 10.
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Cellular basis of itch sensation.
Science. 2009 Sep 18;325(5947):1531-4. doi: 10.1126/science.1174868. Epub 2009 Aug 6.
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TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms.
Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11330-5. doi: 10.1073/pnas.0905605106. Epub 2009 Jun 29.
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Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis.
J Immunol. 2009 May 1;182(9):5836-45. doi: 10.4049/jimmunol.0802999.
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Behavioral differentiation between itch and pain in mouse.
Pain. 2008 Oct 31;139(3):681-687. doi: 10.1016/j.pain.2008.08.002. Epub 2008 Sep 11.
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Histamine-induced itch and its relationship with pain.
Mol Pain. 2008 Jul 31;4:29. doi: 10.1186/1744-8069-4-29.
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A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord.
Nature. 2007 Aug 9;448(7154):700-3. doi: 10.1038/nature06029. Epub 2007 Jul 25.
10
TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase.
J Neurosci. 2007 Feb 28;27(9):2331-7. doi: 10.1523/JNEUROSCI.4643-06.2007.

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